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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zawadzki J V, Weiss G B

Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.

Gen Pharmacol. 1990;21(5):671-5. doi: 10.1016/0306-3623(90)91015-j.

In rabbit aortic smooth muscle, adenosine inhibited the increase induced by norepinephrine (NE) in 45Ca uptake in the presence of KCl (under low affinity Ca2+ uptake conditions) and the NE-induced decrease in 45Ca uptake (under high affinity Ca2+ uptake conditions). Basal 45Ca uptake and KCl-stimulated 45Ca uptake were not altered by adenosine. 2. Adenosine blocked the NE-induced contraction (in high K+) and inhibited both the tonic and phasic components of the NE-induced contraction. 3. Thus, adenosine selectively inhibits release of the intracellular Ca2+ store important for the phasic response to NE and that Ca2+ uptake component important for the NE-induced tonic response.

在兔主动脉平滑肌中，在氯化钾存在的情况下（低亲和力钙摄取条件下），腺苷抑制去甲肾上腺素（NE）诱导的45Ca摄取增加，以及NE诱导的45Ca摄取减少（高亲和力钙摄取条件下）。腺苷不改变基础45Ca摄取和氯化钾刺激的45Ca摄取。2. 腺苷阻断NE诱导的收缩（高钾情况下），并抑制NE诱导收缩的强直和相性成分。3. 因此，腺苷选择性抑制对NE相性反应重要的细胞内钙储存的释放，以及对NE诱导的强直反应重要的钙摄取成分。

Zawadzki J V, Weiss G B

Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.

Gen Pharmacol. 1990;21(5):671-5. doi: 10.1016/0306-3623(90)91015-j.

In rabbit aortic smooth muscle, adenosine inhibited the increase induced by norepinephrine (NE) in 45Ca uptake in the presence of KCl (under low affinity Ca2+ uptake conditions) and the NE-induced decrease in 45Ca uptake (under high affinity Ca2+ uptake conditions). Basal 45Ca uptake and KCl-stimulated 45Ca uptake were not altered by adenosine. 2. Adenosine blocked the NE-induced contraction (in high K+) and inhibited both the tonic and phasic components of the NE-induced contraction. 3. Thus, adenosine selectively inhibits release of the intracellular Ca2+ store important for the phasic response to NE and that Ca2+ uptake component important for the NE-induced tonic response.

在兔主动脉平滑肌中，在氯化钾存在的情况下（低亲和力钙摄取条件下），腺苷抑制去甲肾上腺素（NE）诱导的45Ca摄取增加，以及NE诱导的45Ca摄取减少（高亲和力钙摄取条件下）。腺苷不改变基础45Ca摄取和氯化钾刺激的45Ca摄取。2. 腺苷阻断NE诱导的收缩（高钾情况下），并抑制NE诱导收缩的强直和相性成分。3. 因此，腺苷选择性抑制对NE相性反应重要的细胞内钙储存的释放，以及对NE诱导的强直反应重要的钙摄取成分。