Giliazova A V, Zenin P V, Pronin A Iu, Serkov I L, Khametova K M, Orlova-Morozova E A, Zhukova E V, Kornilaeva G V, Pasternak A O, Lukashov V V, Karamov E V
Vopr Virusol. 2010 Sep-Oct;55(5):25-9.
The Moscow Region is one of the HIV-1-affected subjects of the Russian Federation; there were 34613 HIV-1-infected subjects as of October 31, 2009. To characterize the molecular epidemiology of HIV-1 in the Moscow Region, the investigators obtained and studied HIV-1 variants from 61 infected subjects of the region, who were major risk groups: intravenous drug users (IDUs) and hetero- and homosexually infected persons. Genetic analysis of HIV-1 variants was carried out by sequencing the gag genes (729 nucleotides in length, including full-length protein p17 and partial p24) andlor env (270 nucleotides in length, V3 region) with further phylogenetic analysis. The findings demonstrated that HIV-1 subtype A variants are dominant in the Moscow Region and detectable in 93.5% of IDUs and 100% of heterosexually infected persons. Phylogenetically (and accordingly epidemiologically) unrelated HIV-1 subtype B strains were revealed in 4 patients, including 2 IDUs.
莫斯科地区是俄罗斯联邦受HIV-1影响的地区之一；截至2009年10月31日，有34613名HIV-1感染者。为了描述莫斯科地区HIV-1的分子流行病学特征，研究人员从该地区61名感染个体中获取并研究了HIV-1变异株，这些个体属于主要风险群体：静脉注射吸毒者（IDU）以及异性和同性感染人群。通过对gag基因（长度为729个核苷酸，包括全长蛋白p17和部分p24）和/或env（长度为270个核苷酸，V3区域）进行测序并进一步进行系统发育分析，对HIV-1变异株进行了基因分析。研究结果表明，HIV-1 A亚型变异株在莫斯科地区占主导地位，在93.5%的静脉注射吸毒者和100%的异性感染人群中均可检测到。在4名患者中发现了系统发育上（因此在流行病学上）不相关的HIV-1 B亚型毒株，其中包括2名静脉注射吸毒者。
