Lazouskaya Natallia V, Eremin Vladimir F, Adema Karen W, Gasich Elena L, Baan Elly, Lukashov Vladimir V
Department of Clinical Virology, Institute for Epidemiology and Microbiology, 220114 Minsk, Belarus.
AIDS Res Hum Retroviruses. 2005 Sep;21(9):830-3. doi: 10.1089/aid.2005.21.830.
To study the molecular epidemiology of HIV-1 in Belarus, where the rapid spread of HIV-1 has been registered since 1996, we obtained HIV-1 sequences from 30 individuals living in five cities in both the main geographic areas of the epidemic (Gomel and Minsk regions) and territories where spreading of the epidemic remains limited (Grodno region). Analysis of env V3 and gag p17/p24 sequences demonstrated that infections in all 12 injecting drug users and 14 of 18 individuals infected through sexual contacts were caused by subtype A viruses that are specific for the epidemic in the former Soviet Union (IDU-A viruses), while the remaining four infections were caused by phylogenetically unrelated to each other subtype B viruses. Extrapolation of these results to the total population of HIV-1-infected individuals in Belarus allowed us to estimate that IDU-A viruses account for nearly 95% of HIV-1 infections in Belarus.
为研究白俄罗斯的HIV-1分子流行病学情况（自1996年以来该国已记录到HIV-1的快速传播），我们从居住在疫情主要地理区域（戈梅利和明斯克地区）的五个城市以及疫情传播仍有限的地区（格罗德诺地区）的30个人身上获取了HIV-1序列。对env V3和gag p17/p24序列的分析表明，所有12名注射吸毒者以及18名经性接触感染的个体中的14例感染是由前苏联疫情特有的A亚型病毒（注射吸毒者-A型病毒，IDU-A病毒）引起的，而其余4例感染是由彼此在系统发育上无关的B亚型病毒引起的。将这些结果外推至白俄罗斯HIV-1感染个体的总人口，使我们能够估计IDU-A病毒占白俄罗斯HIV-1感染的近95%。
