Pietraszek M H, Takahashi S, Takada Y, Ohara K, Inatomi H, Kondo N, Ohara K, Takada A
Department of Psychiatry and Physiology, Hamamatsu University School of Medicine, Shizuoka-ken, Japan.
Thromb Res. 1991 Oct 15;64(2):243-52. doi: 10.1016/0049-3848(91)90123-e.
Diurnal changes of serotonin-related factors in whole blood and fibrinolytic activity were determined in depressed patients and healthy controls. Whole blood serotonin concentration of depressed patients showed marked changes throughout daytime, with maximum values in the evening and lowest values in the morning, whereas its metabolite 5-HIAA followed a contrary pattern. The circadian rhythm of 5-HT and 5-HIAA in the control group was quite different from depressed patients. Plasma levels of tPA decreased from 12:30 to 16:30. Concentrations of free plasminogen activator inhibitor (PAI-1) and complex of tPA-PAI-1 decreased from 8:30 to 16:30. Plasma levels of total PAI-1 decreased from 8:30 to 16:30. Plasma levels of the fibrinolytic parameters may be lower in depressive patients than in normal controls. These results support the changes in the circadian rhythm of serotonin and its related substances in the blood of depressive patients.
在抑郁症患者和健康对照者中测定了全血中血清素相关因子的昼夜变化以及纤溶活性。抑郁症患者的全血血清素浓度在白天呈现出显著变化，傍晚时达到最大值，早晨时达到最小值，而其代谢产物5-羟吲哚乙酸（5-HIAA）则呈现相反的模式。对照组中5-羟色胺（5-HT）和5-HIAA的昼夜节律与抑郁症患者有很大不同。组织型纤溶酶原激活物（tPA）的血浆水平从12:30至16:30下降。游离纤溶酶原激活物抑制剂（PAI-1）和tPA-PAI-1复合物的浓度从8:30至16:30下降。总PAI-1的血浆水平从8:30至16:30下降。抑郁症患者的血浆纤溶参数水平可能低于正常对照组。这些结果支持抑郁症患者血液中血清素及其相关物质昼夜节律的变化。
