关于Nutlin的诸多纷扰。 - Suppr

Much ado about Nutlin.

作者信息

Teoh Narci C

出版信息

J Gastroenterol Hepatol. 2011 Feb;26(2):213-5. doi: 10.1111/j.1440-1746.2010.06588.x.

DOI:10.1111/j.1440-1746.2010.06588.x

PMID:21261708

Abstract

摘要

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Much ado about Nutlin.

J Gastroenterol Hepatol. 2011 Feb;26(2):213-5. doi: 10.1111/j.1440-1746.2010.06588.x.

MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro.

J Gastroenterol Hepatol. 2011 Feb;26(2):371-7. doi: 10.1111/j.1440-1746.2010.06440.x.

Nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular carcinoma cells through p53 or p73 signaling pathways.

J Cancer Res Clin Oncol. 2010 Oct;136(10):1597-604. doi: 10.1007/s00432-010-0817-8. Epub 2010 Feb 20.

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

Oncogene. 2007 May 24;26(24):3473-81. doi: 10.1038/sj.onc.1210136. Epub 2006 Dec 4.

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

Oncogene. 2008 Feb 7;27(7):997-1003. doi: 10.1038/sj.onc.1210707. Epub 2007 Aug 13.

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma.

Mol Cancer. 2014 May 31;13:133. doi: 10.1186/1476-4598-13-133.

p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.

PLoS One. 2012;7(5):e37776. doi: 10.1371/journal.pone.0037776. Epub 2012 May 25.

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

Apoptosis. 2011 Jan;16(1):35-44. doi: 10.1007/s10495-010-0538-0.

Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation.

Tumour Biol. 2010 Aug;31(4):287-95. doi: 10.1007/s13277-010-0035-7. Epub 2010 Apr 27.

The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73.

Int J Oncol. 2009 May;34(5):1395-402.

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Much ado about Nutlin.

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