Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Ghent, Belgium.
Microb Biotechnol. 2008 Nov;1(6):507-12. doi: 10.1111/j.1751-7915.2008.00051.x. Epub 2008 Aug 4.
Manganese (II) and manganese-oxidizing bacteria were used as an efficient biological system for the degradation of the xenoestrogen 17α-ethinylestradiol (EE2) at trace concentrations. Mn(2+)-derived higher oxidation states of Mn (Mn(3+), Mn(4+)) by Mn(2+)-oxidizing bacteria mediate the oxidative cleavage of the polycyclic target compound EE2. The presence of manganese (II) was found to be essential for the degradation of EE2 by Leptothrix discophora, Pseudomonas putida MB1, P. putida MB6 and P. putida MB29. Mn(2+)-dependent degradation of EE2 was found to be a slow process, which requires multi-fold excess of Mn(2+) and occurs in the late stationary phase of growth, implying a chemical process taking place. EE2-derived degradation products were shown to no longer exhibit undesirable estrogenic activity.
锰（II）和锰氧化菌被用作一种有效的生物系统，用于降解痕量浓度的外源性雌激素 17α-乙炔基雌二醇（EE2）。锰（II）氧化菌介导的锰（Mn（3+），Mn（4+））衍生的更高氧化态的锰（Mn（3+），Mn（4+））介导了多环目标化合物 EE2 的氧化断裂。发现锰（II）的存在对于 Leptothrix discophora、Pseudomonas putida MB1、P. putida MB6 和 P. putida MB29 降解 EE2 是必不可少的。发现锰（II）依赖的 EE2 降解是一个缓慢的过程，需要多倍过量的 Mn（2+），并且发生在生长的晚期稳定期，这意味着发生了一个化学过程。EE2 衍生的降解产物不再表现出不良的雌激素活性。
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