Demaria Francesca, Suleiman Marcel, Corvini Philippe, Junier Pilar
Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern, Muttenz, Switzerland.
Laboratory of Microbiology, Institute of Biology, University of Neuchatel, Neuchatel, Switzerland.
Microb Biotechnol. 2025 Jan;18(1):e70084. doi: 10.1111/1751-7915.70084.
The inadequate removal of pharmaceuticals and personal care products (PPCPs) by traditional wastewater treatment plants (WWTPs) poses a significant environmental and public health challenge. Residual PPCPs find their way into aquatic ecosystems, leading to bioaccumulation in aquatic biota, the dissemination of antibiotic resistance genes (ARGs), and contamination of both water sources and vegetables. These persistent pollutants can have negative effects on human health, ranging from antibiotic resistance development to endocrine disruption. To mitigate these risks, there is a growing interest in exploiting microorganisms and their enzymes for bioremediation purposes. By harnessing the metabolic capabilities of microbial communities, PPCPs can be efficiently degraded, transformed, or sequestered in water systems. Additionally, microbial communities exhibit remarkable adaptability and resilience to diverse PPCP contaminants, further underscoring their potential as sustainable and cost-effective solutions for water treatment. This review explores the promise of microbial bioremediation as an approach to addressing the complex challenges posed by persistent PPCP contamination, emphasising its potential to safeguard both environmental integrity and human well-being.
传统污水处理厂（WWTPs）对药物和个人护理产品（PPCPs）去除不充分，这对环境和公众健康构成了重大挑战。残留的PPCPs进入水生生态系统，导致在水生生物中生物累积、抗生素抗性基因（ARGs）传播以及水源和蔬菜受到污染。这些持久性污染物会对人类健康产生负面影响，从抗生素抗性发展到内分泌干扰。为了降低这些风险，人们越来越关注利用微生物及其酶进行生物修复。通过利用微生物群落的代谢能力，PPCPs可以在水系统中被有效降解、转化或隔离。此外，微生物群落对各种PPCP污染物表现出显著的适应性和恢复力，进一步突出了它们作为可持续且具有成本效益的水处理解决方案的潜力。本综述探讨了微生物生物修复作为应对持久性PPCP污染带来的复杂挑战的一种方法的前景，强调其保护环境完整性和人类福祉的潜力。
