Cocchieri M, Alunni G F, Del Favero A, Fortunati F, Bardelli G, Capponi E A, Regi L, Boschetti E
Divisione di Cardiologia di Perugia, Italia.
Cardiology. 1990;77 Suppl 5:36-42. doi: 10.1159/000174694.
Twenty-three patients with mild heart failure (I-II NYHA classes) on digitalis and diuretics were assigned to the following treatment in a random and double-blind fashion: ibopamine-captopril, ibopamine-placebo, captopril-placebo, and placebo-placebo. The doses of captopril and ibopamine were respectively 25 mg t.i.d. and 100 mg t.i.d. The incremental exercise time (until exhaustion) and the peak VO2 (oxygen consumption), the indexes of left ventricular function (by echo and nuclear stethoscope) and ventricular arrhythmias (evaluated by prolonged Holter monitoring) were assessed before randomization, at 45 days and at 3 months. Ejection fraction, exercise time, peak VO2, ventricular arrhythmias and heart rate (at rest and during exercise) appeared to be equally unaffected by each treatment. Our results show that ibopamine exerts no significant effects on either heart rate or ventricular arrhythmias and that indexes of left ventricular function are not modified by any treatment in mild congestive heart failure.
23例正在服用洋地黄和利尿剂的轻度心力衰竭（纽约心脏协会心功能I-II级）患者被随机双盲分为以下治疗组：异波帕胺-卡托普利组、异波帕胺-安慰剂组、卡托普利-安慰剂组和安慰剂-安慰剂组。卡托普利和异波帕胺的剂量分别为每日3次，每次25mg和每日3次，每次100mg。在随机分组前、45天时和3个月时评估递增运动时间（直至疲劳）和峰值VO2（耗氧量）、左心室功能指标（通过超声心动图和核听诊器）以及室性心律失常（通过延长的动态心电图监测评估）。射血分数、运动时间、峰值VO2、室性心律失常和心率（静息时和运动时）似乎均不受各治疗的影响。我们的结果表明，异波帕胺对心率或室性心律失常均无显著影响，且在轻度充血性心力衰竭中，左心室功能指标不会因任何治疗而改变。
