Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, ROC.
Am J Nephrol. 2011;33(6):510-4. doi: 10.1159/000327822. Epub 2011 May 5.
Taiwan has the highest incidence and prevalence of end-stage renal disease worldwide. Haptoglobin (Hp) has a role in renal protection, and there are known differences in the function of different Hp alleles. We aim to study the association between Hp genotype and chronic kidney disease (CKD) in Taiwan.
We performed one hospital-based, age-matched case-control study of 213 patients with CKD and 213 controls to evaluate the association between Hp polymorphism and CKD. Three major Hp genotypes were determined using polymerase chain reaction and electrophoresis. An unconditional logistic regression model was used to identify the associated risk factors for the development of CKD.
The frequency of Hp2-2 genotype and Hp(2) allele was significantly higher in the CKD group than in controls (p = 0.032 and 0.024, respectively). After adjustment for covariates, the Hp2-2 genotype (vs. Hp1-1; OR 3.841) remained significantly associated with the development of CKD, together with diabetes (OR 3.131), hypertension (OR 1.748) and dyslipidemia (OR 1.646).
This present study shows that Hp2-2 genotype is an independent risk factor for CKD. Determination of the Hp genotype may be of potential value to the prediction of genetic risk for CKD.
台湾地区拥有全球最高的终末期肾病发病率和患病率。触珠蛋白（Hp）在肾脏保护中发挥作用，不同 Hp 等位基因的功能存在已知差异。我们旨在研究 Hp 基因型与台湾地区慢性肾脏病（CKD）之间的关联。
我们进行了一项基于医院的、年龄匹配的 213 例 CKD 患者和 213 例对照的病例对照研究，以评估 Hp 多态性与 CKD 之间的关系。使用聚合酶链反应和电泳法确定三种主要的 Hp 基因型。采用非条件逻辑回归模型确定 CKD 发生的相关危险因素。
CKD 组 Hp2-2 基因型和 Hp(2)等位基因的频率明显高于对照组（p = 0.032 和 0.024）。调整协变量后，Hp2-2 基因型（与 Hp1-1 相比；OR 3.841）仍然与 CKD 的发生显著相关，同时与糖尿病（OR 3.131）、高血压（OR 1.748）和血脂异常（OR 1.646）相关。
本研究表明 Hp2-2 基因型是 CKD 的独立危险因素。Hp 基因型的确定可能对预测 CKD 的遗传风险具有潜在价值。
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