促甲状腺激素释放激素对自主神经系统的影响通过心电图R-R间期变化来确定。

Influence of thyrotropin-releasing hormone on autonomic nervous system determined by the variations in R-R interval on electrocardiogram.

作者信息

Iwashita A, Kobayashi I, Inukai T, Takahashi M, Ishii A, Ohshima K, Mori M, Shimomura Y, Kobayashi S

机构信息

First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Exp Clin Endocrinol. 1990 Sep;96(1):121-4. doi: 10.1055/s-0029-1210999.

DOI:10.1055/s-0029-1210999

PMID:2126239

Abstract

The change of variation in R-R interval on electrocardiograms (CVq) was examined in healthy subjects and patients with Graves' disease before and after an intravenous administration of 500 micrograms of Thyrotropin-releasing hormone (TRH). CVq was significantly elevated after TRH stimulation and returned to the control level within 120 min. This phenomenon was found not only in healthy subjects but also in patients with untreated Graves' disease whose levels of CVq were lower than in normal subjects. Pretreatment with atropine inhibited the response of CVq to TRH. These data suggest that TRH has a stimulatory effect on the parasympathetic nervous system, determined by the variations in R-R interval.

摘要

在健康受试者和格雷夫斯病患者静脉注射500微克促甲状腺激素释放激素（TRH）前后，检测心电图R-R间期变化率（CVq）。TRH刺激后CVq显著升高，并在120分钟内恢复到对照水平。这种现象不仅在健康受试者中发现，而且在未经治疗的格雷夫斯病患者中也发现，其CVq水平低于正常受试者。阿托品预处理可抑制CVq对TRH的反应。这些数据表明，TRH对副交感神经系统有刺激作用，由R-R间期变化决定。