Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Virology. 2011 Mar 15;411(2):316-24. doi: 10.1016/j.virol.2010.12.043. Epub 2011 Jan 22.
Infection of host cells by a variety of viruses results in programmed cell death or apoptosis. In many cases, early events in virus replication that occur prior to synthesis of viral proteins and replication of viral genomes directly or indirectly activate signaling pathways that culminate in cell death. Using examples of viruses for which prodeath signaling is better defined, this review will describe how cell entry steps including virus attachment to receptors, virus uncoating in endosomes, and events that occur following membrane penetration lead to apoptosis. The relevance and physiologic consequences of early induction of prodeath signaling to viral pathogenesis also will be discussed.
多种病毒感染宿主细胞会导致细胞程序性死亡或细胞凋亡。在许多情况下,病毒复制过程中发生在病毒蛋白合成和病毒基因组复制之前的早期事件,直接或间接地激活了信号通路,最终导致细胞死亡。本文将通过对已明确具有促死亡信号的病毒的举例,描述病毒进入宿主细胞的步骤(包括病毒与受体结合、病毒在内体中脱壳以及膜穿透后发生的事件)如何导致细胞凋亡。此外,本文还将讨论早期诱导促死亡信号对病毒发病机制的相关性及其生理后果。