Suppr超能文献

进入杀伤区:病毒进入时的死亡信号启动。

Enter the kill zone: initiation of death signaling during virus entry.

机构信息

Department of Biology, Indiana University, Bloomington, IN 47405, USA.

出版信息

Virology. 2011 Mar 15;411(2):316-24. doi: 10.1016/j.virol.2010.12.043. Epub 2011 Jan 22.

Abstract

Infection of host cells by a variety of viruses results in programmed cell death or apoptosis. In many cases, early events in virus replication that occur prior to synthesis of viral proteins and replication of viral genomes directly or indirectly activate signaling pathways that culminate in cell death. Using examples of viruses for which prodeath signaling is better defined, this review will describe how cell entry steps including virus attachment to receptors, virus uncoating in endosomes, and events that occur following membrane penetration lead to apoptosis. The relevance and physiologic consequences of early induction of prodeath signaling to viral pathogenesis also will be discussed.

摘要

多种病毒感染宿主细胞会导致细胞程序性死亡或细胞凋亡。在许多情况下,病毒复制过程中发生在病毒蛋白合成和病毒基因组复制之前的早期事件,直接或间接地激活了信号通路,最终导致细胞死亡。本文将通过对已明确具有促死亡信号的病毒的举例,描述病毒进入宿主细胞的步骤(包括病毒与受体结合、病毒在内体中脱壳以及膜穿透后发生的事件)如何导致细胞凋亡。此外,本文还将讨论早期诱导促死亡信号对病毒发病机制的相关性及其生理后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be64/7126532/9bf9976af4fc/gr1_lrg.jpg

相似文献

1
Enter the kill zone: initiation of death signaling during virus entry.
Virology. 2011 Mar 15;411(2):316-24. doi: 10.1016/j.virol.2010.12.043. Epub 2011 Jan 22.
2
Principles of Virus Uncoating: Cues and the Snooker Ball.
Traffic. 2016 Jun;17(6):569-92. doi: 10.1111/tra.12387. Epub 2016 Mar 31.
3
Viral escape from endosomes and host detection at a glance.
J Cell Sci. 2018 Aug 3;131(15):jcs216259. doi: 10.1242/jcs.216259.
4
Viral apoptotic mimicry.
Nat Rev Microbiol. 2015 Aug;13(8):461-9. doi: 10.1038/nrmicro3469. Epub 2015 Jun 8.
5
How do viruses control mitochondria-mediated apoptosis?
Virus Res. 2015 Nov 2;209:45-55. doi: 10.1016/j.virusres.2015.02.026. Epub 2015 Mar 1.
6
Dengue Virus Genome Uncoating Requires Ubiquitination.
mBio. 2016 Jun 28;7(3):e00804-16. doi: 10.1128/mBio.00804-16.
7
Virus-Receptor Interactions: The Key to Cellular Invasion.
J Mol Biol. 2018 Aug 17;430(17):2590-2611. doi: 10.1016/j.jmb.2018.06.024. Epub 2018 Jun 18.
8
Ephrin-Eph signaling usage by a variety of viruses.
Pharmacol Res. 2020 Sep;159:105038. doi: 10.1016/j.phrs.2020.105038. Epub 2020 Jun 18.
10
Virus Infection and Death Receptor-Mediated Apoptosis.
Viruses. 2017 Oct 27;9(11):316. doi: 10.3390/v9110316.

引用本文的文献

1
Caspase-mediated cleavage of nucleocapsid protein of a protease-independent porcine epidemic diarrhea virus strain.
Virus Res. 2020 Aug;285:198026. doi: 10.1016/j.virusres.2020.198026. Epub 2020 May 18.
4
Innate immunity to adenovirus.
Hum Gene Ther. 2014 Apr;25(4):265-84. doi: 10.1089/hum.2014.001. Epub 2014 Apr 8.
5
Recent progress in studies of arterivirus- and coronavirus-host interactions.
Viruses. 2012 Jun;4(6):980-1010. doi: 10.3390/v4060980. Epub 2012 Jun 19.
6
Role of apoptosis in disease.
Aging (Albany NY). 2012 May;4(5):330-49. doi: 10.18632/aging.100459.
7
Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman"?
Rev Med Virol. 2012 Sep;22(5):323-38. doi: 10.1002/rmv.1714. Epub 2012 Apr 18.
8
Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis.
Cell Death Dis. 2012 Mar 8;3(3):e277. doi: 10.1038/cddis.2012.18.

本文引用的文献

2
Bid regulates the pathogenesis of neurotropic reovirus.
PLoS Pathog. 2010 Jul 1;6(7):e1000980. doi: 10.1371/journal.ppat.1000980.
3
4
From touchdown to transcription: the reovirus cell entry pathway.
Curr Top Microbiol Immunol. 2010;343:91-119. doi: 10.1007/82_2010_32.
5
Viral apoptosis is induced by IRF-3-mediated activation of Bax.
EMBO J. 2010 May 19;29(10):1762-73. doi: 10.1038/emboj.2010.50. Epub 2010 Apr 1.
6
Caspases and kinases in a death grip.
Cell. 2009 Sep 4;138(5):838-54. doi: 10.1016/j.cell.2009.08.021.
7
Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.
PLoS Pathog. 2008 Dec;4(12):e1000248. doi: 10.1371/journal.ppat.1000248. Epub 2008 Dec 26.
8
Viral membrane fusion.
Nat Struct Mol Biol. 2008 Jul;15(7):690-8. doi: 10.1038/nsmb.1456.
9
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.
Crit Rev Biochem Mol Biol. 2008 May-Jun;43(3):189-219. doi: 10.1080/10409230802058320.
10
Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak.
Cell Death Differ. 2008 Sep;15(9):1396-407. doi: 10.1038/cdd.2008.61. Epub 2008 Apr 25.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验