Favaloro Bartolo, Allocati Nerino, Graziano Vincenzo, Di Ilio Carmine, De Laurenzi Vincenzo
Dipartimento di Scienze Biomediche, Universita' "G. d'Annunzio" Chieti-Pescara, Italy.
Aging (Albany NY). 2012 May;4(5):330-49. doi: 10.18632/aging.100459.
Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.
自从细胞凋亡被首次描述以来，人们又描述了许多不同形式的细胞死亡。在这篇综述中，我们将重点关注经典的半胱天冬酶依赖性细胞凋亡及其与疾病相关的变体。五十多年的研究已经阐明了细胞凋亡信号传导所涉及的分子机制，并且表明这些途径的改变会导致人类疾病。事实上，细胞凋亡的减少和增加都可能导致病理状态。最近，这些发现促使了基于细胞凋亡调控的治疗方法的发展，其中一些正在进行临床试验或已进入医学实践。
