Department of Oral and Craniofacial Health Science, College of Dentistry, University of Sharjah, United Arab Emirates.
Diab Vasc Dis Res. 2011 Jan;8(1):22-8. doi: 10.1177/1479164110390243.
The aim of this study was to assess the salivary content of lipid peroxidation and antioxidants in patients with type 2 diabetes.
We studied 25 patients with type 2 diabetes and other 25 age- and sex-matched health control. To evaluate the oxidative status we measured the levels of malondialdehyde (MDA) in the saliva and serum of all participants. Lipid profile was also estimated through measuring total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) levels. Antioxidant levels were also assessed through measuring the salivary and serum concentration of uric acid, superoxide dismutase and reduced glutathione (GSH).
The high concentration of lipid fractions in saliva usually follows that recorded in serum. Salivary MDA levels, a product of lipid peroxidation, were significantly increased among diabetics together with uric acid. However, GSH levels were similar to those of the control group.
Lipid peroxidation and antioxidant parameters assessed in saliva of diabetic patients may be of great importance in evaluating the disease activity and severity. The increase in lipid peroxidation and the tendency of antioxidants to rise in diabetes is probably due to an adaptive response to the pro-oxidant status of diabetes.
本研究旨在评估 2 型糖尿病患者唾液中的脂质过氧化和抗氧化剂含量。
我们研究了 25 例 2 型糖尿病患者和 25 例年龄和性别匹配的健康对照者。为了评估氧化状态，我们测量了所有参与者唾液和血清中的丙二醛（MDA）水平。通过测量总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和极低密度脂蛋白胆固醇（VLDL-C）水平来评估血脂谱。还通过测量唾液和血清中尿酸、超氧化物歧化酶和还原型谷胱甘肽（GSH）的浓度来评估抗氧化剂水平。
唾液中脂质分数的高浓度通常与血清中记录的相同。糖尿病患者唾液中的 MDA 水平（脂质过氧化的产物）显著升高，同时尿酸也升高。然而，GSH 水平与对照组相似。
在评估疾病的活动度和严重程度时，糖尿病患者唾液中的脂质过氧化和抗氧化剂参数可能非常重要。糖尿病患者脂质过氧化增加和抗氧化剂升高的趋势可能是对糖尿病促氧化状态的一种适应性反应。
