Assiri Khalil Ibrahim, Alqahtani Ali Mosfer A, Alqarni Abdullah, Assiri Hassan Ahmed, Alassiri Saeed, Shaik Samiunnisa Begum, Dawasaz Ali Azhar, Hameed Mohammad Shahul
Department of Diagnostic Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Department of Oral Medicine and Radiology, Ragas Dental College & Hospital, Chennai 600119, India.
J Clin Med. 2024 Nov 22;13(23):7051. doi: 10.3390/jcm13237051.
: The use of salivary biomarkers offers a non-invasive approach to understanding the metabolic and inflammatory status of hypertensive patients. This study aimed to quantify the salivary nitric oxide (NO), total cholesterol, triglycerides, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) levels in hypertensive individuals and healthy controls in a sub-population in Saudi Arabia. : This cross-sectional study comprised 40 hypertensive patients (test group, 40-50 years old) and 40 age-matched healthy controls who visited the dental hospital in the College of Dentistry, King Khalid University, for dental treatment. Nitric oxide, total cholesterol, triglycerides, HDL, and LDL levels in saliva were assessed. An independent sample t-test was used to compare the results between the hypertensive and control groups. : The mean triglyceride and cholesterol levels in the test group were significantly higher ( < 0.05) than those in the control group. Alternatively, the NO level in the test group was significantly ( = 0.014) lower than that in the controls. The triglyceride level was significantly correlated with age in the test group ( = 0.04). : This study demonstrated significant differences in the nitrate levels and lipid profiles between hypertensive patients and healthy individuals in a sub-population in Saudi Arabia. The findings indicate that saliva can be used as a non-invasive diagnostic tool for assessing nitrate levels and the lipid profile. However, additional studies with larger sample sizes and more precise testing parameters are required to validate the findings.
唾液生物标志物的应用为了解高血压患者的代谢和炎症状态提供了一种非侵入性方法。本研究旨在量化沙特阿拉伯某亚人群中高血压个体和健康对照者的唾液一氧化氮（NO）、总胆固醇、甘油三酯、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平。：这项横断面研究包括40名高血压患者（试验组，年龄40 - 50岁）和40名年龄匹配的健康对照者，他们前往哈利德王大学牙科学院的牙科医院接受牙科治疗。评估了唾液中的一氧化氮、总胆固醇、甘油三酯、HDL和LDL水平。使用独立样本t检验比较高血压组和对照组的结果。：试验组的平均甘油三酯和胆固醇水平显著高于对照组（<0.05）。另外，试验组的NO水平显著低于对照组（=0.014）。试验组中甘油三酯水平与年龄显著相关（=0.04）。：本研究表明，沙特阿拉伯某亚人群中高血压患者和健康个体之间的硝酸盐水平和血脂谱存在显著差异。研究结果表明，唾液可作为评估硝酸盐水平和血脂谱的非侵入性诊断工具。然而，需要更多样本量更大、测试参数更精确的研究来验证这些发现。
