Jadrić Radivoj, Hasić Sabaheta, Kiseljaković Emina, Corić Jozo, Prnjavorac Besim, Winterhalter-Jadrić Mira
Institute for Physiology and Biochemistry, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Glas (Zenica). 2011 Feb;8(1):146-50.
To determine the lipoprotein profile of voluntary blood donors, and on the basis of parameters to evaluate the risk of atherosclerosis.
The study included voluntary blood donors of both sexes. Participants were divided into two groups. The first group of subjects consisted of men and women in menopause (BD 1). The second group consisted of women in reproductive age (BD 2). Analysis of concentration of lipoproteins was performed by direct determination of total cholesterol, LDL-C and HDL-C. From the total serum cholesterol and concentration of lipoproteins ratios of total cholesterol/HDL-C ratio and LDL-C/HDL-C were calculated.
Significantly higher concentration of LDL-C was obtained in the serum of BD 1, compared to LDL-C in the serum of BD 2, within the reference range. Mean concentration of HDL-C in the serum of BD 2 group was higher than the values measured in the BD group 1, without significant difference. The ratio of total cholesterol/HDL-C showed significantly higher values in the BD 1 group compared with results in the BD 2 group. Significantly higher values in the BD group 1 were observed for the ratio of LDL-C/HDL-C. Obtained results showed that all voluntary blood donors had a concentration of individual lipoprotein fractions in a lower risk range for atherosclerosis development.
Female voluntary blood donors in reproductive age have a more favorable lipid status in relation to the voluntary blood donors, men and women in menopause, indicating that this population of women is exposed to lower risk of developing atherosclerosis.
确定无偿献血者的脂蛋白谱，并根据相关参数评估动脉粥样硬化风险。
该研究纳入了男女无偿献血者。参与者被分为两组。第一组受试者包括绝经后的男性和女性（BD 1）。第二组由育龄期女性组成（BD 2）。通过直接测定总胆固醇、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）来分析脂蛋白浓度。根据总血清胆固醇和脂蛋白浓度计算总胆固醇/HDL-C比值以及LDL-C/HDL-C比值。
BD 1组血清中LDL-C浓度显著高于BD 2组血清中的LDL-C浓度，且均在参考范围内。BD 2组血清中HDL-C的平均浓度高于BD 1组测得的值，但无显著差异。BD 1组的总胆固醇/HDL-C比值显著高于BD 2组。BD 1组的LDL-C/HDL-C比值也显著更高。所得结果表明，所有无偿献血者的单个脂蛋白组分浓度均处于动脉粥样硬化发展的低风险范围内。
与绝经后的男性和女性无偿献血者相比，育龄期女性无偿献血者的脂质状况更有利，这表明该女性群体发生动脉粥样硬化的风险较低。
