Khomenko A G, Kryzhanovskiĭ D G, Kaminskaia G O, Serebrianaia B A, Balta N G
Ter Arkh. 1990;62(9):25-9.
In 80 patients with pulmonary tuberculosis aggravated by stage I-IIB cardiopulmonary insufficiency, the multimodality therapy included vektarion improving the ventilation/perfusion correlations (29 patients) and the combination of metabolic correctors (glutamevit and riboxin) (51 patients). The population analysis of peripheral blood erythrocytes (by the method of acidic erythrograms), the fractional composition of hemoglobin, the concentration of 2,3-diphosphoglycerine acid and the isozymic spectrum of LDH in erythrocytes served as methods of the treatment efficacy control. The treatment with vektarion noticeably reduced hypoxemia which was accompanied by positive shifts in erythrocyte metabolism and in the hemoglobin spectrum, producing but a negligible action on the population composition of erythrocytes. The combination of the metabolic correctors exerted a lesser effect on the fractional composition of hemoglobins, producing a well-defined positive action on erythrocyte function, decelerating the processes of their ageing. It is concluded that the highest positive effect may be produced by the combined use of all the three drugs bearing in mind their action mode.
在80例因I-IIB期心肺功能不全而加重的肺结核患者中，多模式治疗包括使用改善通气/灌注相关性的维克塔里翁（29例患者）以及代谢校正剂（谷氨酰胺维生素和核糖核酸）联合治疗（51例患者）。采用外周血红细胞群体分析（酸性红细胞图法）、血红蛋白的组分、2,3-二磷酸甘油酸浓度以及红细胞中乳酸脱氢酶的同工酶谱作为治疗效果控制方法。使用维克塔里翁治疗可显著降低低氧血症，同时红细胞代谢和血红蛋白谱出现正向变化，对红细胞群体组成的影响可忽略不计。代谢校正剂联合使用对血红蛋白组分的影响较小，但对红细胞功能有明确的正向作用，减缓其衰老过程。得出的结论是，考虑到这三种药物的作用方式，联合使用它们可能产生最大的正向效果。
