Goebel K M, Richter H, Schneider J, Kaffarnik H
Wien Med Wochenschr. 1979 Sep 15;129(15):424-7.
In patients with shock the metabolism and O2-function of the erythrocytes were studied following separation according to cell-age by density layer centrifugation using a new supporting medium. Metabolic acidosis in patients with postoperative shock (n=8) and in patients with shock due to severe congestive heart failure (n=12) provoked decreased levels of 2,3-diphosphoglycerate, ADP, ATP and reduced glutathione. Raised lactate/pyruvate ratios were observed also in both groups, whereas the O2-function of the erythrocytes was markedly disturbed in all patients. Patients of both groups received glucocorticoid-infusions resulting in a significant improvement of the extent and pattern of the red cell metabolic disorder.
对休克患者，使用一种新型支持介质，通过密度梯度离心按细胞年龄分离红细胞后，研究其代谢和氧功能。术后休克患者（n = 8）和严重充血性心力衰竭所致休克患者（n = 12）的代谢性酸中毒导致2,3 - 二磷酸甘油酸、ADP、ATP和还原型谷胱甘肽水平降低。两组患者均观察到乳酸/丙酮酸比值升高，而所有患者红细胞的氧功能均受到明显干扰。两组患者均接受糖皮质激素输注，红细胞代谢紊乱的程度和模式得到显著改善。
