液流网络中带有流体动力阱的液滴串的行为。
Behavior of a train of droplets in a fluidic network with hydrodynamic traps.
机构信息
Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA.
出版信息
Biomicrofluidics. 2010 Dec 6;4(4):44110. doi: 10.1063/1.3523053.
Abstract
The behavior of a droplet train in a microfluidic network with hydrodynamic traps in which the hydrodynamic resistive properties of the network are varied is investigated. The flow resistance of the network and the individual droplets guide the movement of droplets in the network. In general, the flow behavior transitions from the droplets being immobilized in the hydrodynamic traps at low flow rates to breaking up and squeezing of the droplets at higher flow rates. A state diagram characterizing these dynamics is presented. A simple hydrodynamic circuit model that treats droplets as fluidic resistors is discussed, which predicts the experimentally observed flow rates for droplet trapping in the network. This study should enable the rational design of microfuidic devices for passive storage of nanoliter-scale drops.
摘要
研究了在具有流体动力陷阱的微流控网络中液滴链的行为，其中网络的流体动力阻力特性发生了变化。网络的流动阻力和单个液滴引导液滴在网络中的运动。一般来说，流动行为从低流速下液滴在流体动力陷阱中固定不动转变为更高流速下液滴的破裂和挤压。呈现了一个表征这些动力学的状态图。讨论了一种将液滴视为流体电阻器的简单流体动力学电路模型，该模型预测了实验观察到的网络中液滴捕获的流速。这项研究应该能够为纳米升规模液滴的被动存储设计合理的微流控设备。
相似文献
1
Behavior of a train of droplets in a fluidic network with hydrodynamic traps.液流网络中带有流体动力阱的液滴串的行为。
Biomicrofluidics. 2010 Dec 6;4(4):44110. doi: 10.1063/1.3523053.
2
Trapping a moving droplet train by bubble guidance in microfluidic networks.在微流控网络中通过气泡引导捕获移动的液滴序列
RSC Adv. 2018 Feb 27;8(16):8787-8794. doi: 10.1039/c7ra13507f. eCollection 2018 Feb 23.
3
Simple Method for On-Demand Droplet Trapping in a Microfluidic Device Based on the Concept of Hydrodynamic Resistance.基于流体动力阻力概念的微流控装置中按需液滴捕获的简单方法。
Langmuir. 2024 May 7;40(18):9406-9413. doi: 10.1021/acs.langmuir.3c03452. Epub 2024 Apr 23.
4
Pillar-induced droplet merging in microfluidic circuits.微流控电路中柱体诱导的液滴合并
Lab Chip. 2008 Nov;8(11):1837-41. doi: 10.1039/b813325e. Epub 2008 Oct 8.
5
Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence.用于可控液滴膨胀与聚结的微流控腔室设计
Micromachines (Basel). 2020 Apr 10;11(4):394. doi: 10.3390/mi11040394.
6
Extracting the hydrodynamic resistance of droplets from their behavior in microchannel networks.从液滴在微通道网络中的行为中提取液滴的流体动力阻力。
Biomicrofluidics. 2009 Mar 30;3(1):12804. doi: 10.1063/1.3109686.
7
On demand nanoliter-scale microfluidic droplet generation, injection, and mixing using a passive microfluidic device.按需纳升级微流控液滴生成、注入和混合采用被动微流控器件。
Biomicrofluidics. 2015 Feb 12;9(1):014119. doi: 10.1063/1.4907895. eCollection 2015 Jan.
8
Hydrodynamic trapping for rapid assembly and in situ electrical characterization of droplet interface bilayer arrays.液力捕获用于快速组装和液滴界面双层阵列的原位电特性研究。
Lab Chip. 2016 Sep 21;16(18):3576-88. doi: 10.1039/c6lc00810k. Epub 2016 Aug 11.
9
High-efficiency single cell encapsulation and size selective capture of cells in picoliter droplets based on hydrodynamic micro-vortices.基于流体动力微涡旋的皮升级液滴中单细胞高效包封和尺寸选择性捕获细胞。
Lab Chip. 2017 Dec 5;17(24):4324-4333. doi: 10.1039/c7lc00972k.
10
Fluidic low pass filter for hydrodynamic flow stabilization in microfluidic environments.用于微流控环境中流体流动稳定的流体制式低通滤波器。
Lab Chip. 2012 Apr 24;12(10):1881-9. doi: 10.1039/c2lc21163g. Epub 2012 Mar 21.
引用本文的文献
1
Droplet Generation and Manipulation in Microfluidics: A Comprehensive Overview of Passive and Active Strategies.微流控中的液滴生成与操控：被动与主动策略的全面概述
Biosensors (Basel). 2025 May 29;15(6):345. doi: 10.3390/bios15060345.
2
Programmable Control of Nanoliter Droplet Arrays using Membrane Displacement Traps.利用膜位移阱对纳升液滴阵列进行可编程控制。
Adv Mater Technol. 2023 Nov 10;8(21). doi: 10.1002/admt.202300963. Epub 2023 Aug 15.
3
Trapping a moving droplet train by bubble guidance in microfluidic networks.在微流控网络中通过气泡引导捕获移动的液滴序列
RSC Adv. 2018 Feb 27;8(16):8787-8794. doi: 10.1039/c7ra13507f. eCollection 2018 Feb 23.
4
Deterministic assembly of chromosome ensembles in a programmable membrane trap array.可编程膜阱阵列中染色体组的确定性组装。
Biofabrication. 2021 Jul 20;13(4). doi: 10.1088/1758-5090/ac1258.
5
Microfluidic Droplet-Storage Array.微流控液滴存储阵列
Micromachines (Basel). 2020 Jun 23;11(6):608. doi: 10.3390/mi11060608.
6
Microfluidic Chamber Design for Controlled Droplet Expansion and Coalescence.用于可控液滴膨胀与聚结的微流控腔室设计
Micromachines (Basel). 2020 Apr 10;11(4):394. doi: 10.3390/mi11040394.
7
Elaboration of the Demulsification Process of W/O Emulsion with Three-Dimensional Electric Spiral Plate-Type Microchannel.三维电螺旋板式微通道对水包油乳液破乳过程的阐述
Micromachines (Basel). 2019 Nov 1;10(11):751. doi: 10.3390/mi10110751.
8
DropSOAC: Stabilizing Microfluidic Drops for Time-Lapse Quantification of Single-Cell Bacterial Physiology.DropSOAC：稳定微流体液滴用于单细胞细菌生理学的延时定量分析
Front Microbiol. 2019 Sep 24;10:2112. doi: 10.3389/fmicb.2019.02112. eCollection 2019.
9
Time Sequential Single-Cell Patterning with High Efficiency and High Density.高效高密度的时间序列单细胞图案化。
Sensors (Basel). 2018 Oct 29;18(11):3672. doi: 10.3390/s18113672.
10
The nematocyst's sting is driven by the tubule moving front.刺丝囊的刺是由小管向前移动驱动的。
J R Soc Interface. 2017 Mar;14(128). doi: 10.1098/rsif.2016.0917.
本文引用的文献
1
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).聚二甲基硅氧烷微流控系统的快速成型
Anal Chem. 1998 Dec 1;70(23):4974-84. doi: 10.1021/ac980656z.
2
Microfluidic parallel circuit for measurement of hydraulic resistance.微流控平行电路用于测量水力阻力。
Biomicrofluidics. 2010 Aug 31;4(3):034110. doi: 10.1063/1.3486609.
3
Dynamics of microfluidic droplets.微流控液滴动力学。
Lab Chip. 2010 Aug 21;10(16):2032-45. doi: 10.1039/c001191f. Epub 2010 Jun 18.
4
Self-digitization of sample volumes.样本量的自我数字化。
Anal Chem. 2010 Jul 1;82(13):5707-17. doi: 10.1021/ac100713u.
5
Nanoliter multiplex PCR arrays on a SlipChip.在 SlipChip 上进行纳升级多重 PCR 阵列。
Anal Chem. 2010 Jun 1;82(11):4606-12. doi: 10.1021/ac1007249.
6
Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction.作为用于气液化学反应的纳升反应器的微流控液滴捕获阵列
Electrophoresis. 2009 Sep;30(18):3181-8. doi: 10.1002/elps.200900331.
7
Extracting the hydrodynamic resistance of droplets from their behavior in microchannel networks.从液滴在微通道网络中的行为中提取液滴的流体动力阻力。
Biomicrofluidics. 2009 Mar 30;3(1):12804. doi: 10.1063/1.3109686.
8
SlipChip.滑动芯片
Lab Chip. 2009 Aug 21;9(16):2286-92. doi: 10.1039/b908978k. Epub 2009 May 15.
9
Using Microfluidics to Decouple Nucleation and Growth of Protein Crystals.利用微流控技术解耦蛋白质晶体的成核与生长
Cryst Growth Des. 2007;7(11):2192-2194. doi: 10.1021/cg700688f.
10
On-demand microfluidic droplet trapping and fusion for on-chip static droplet assays.用于芯片上静态液滴分析的按需微流控液滴捕获与融合
Lab Chip. 2009 Jun 7;9(11):1504-6. doi: 10.1039/b903468d. Epub 2009 Apr 22.
Zotero 插件