Biomicrofluidics. 2010 Dec 6;4(4):46505. doi: 10.1063/1.3523471.
We proposed and fabricated multiscale transparent arteriole and capillary vessel models with circular cross sections of 10-500 μm using photolithography. The circularities of the fabricated 10, 50, and 500 μm diameter microchannels were 84.0%, 61.5%, and 82.3%, respectively. Next, we connected these different models to realize a circulation type blood vessel model simulating arteriole networks. We proposed a novel connection method using an intermediate connector made of wax, which we used to connect these models to make a circulation model. In flow experiments, the fabricated models showed no leakage and circulation models with seamless connections were achieved.
我们使用光刻技术提出并制造了具有 10-500μm 圆形横截面的多尺度透明小动脉和毛细血管模型。所制造的 10、50 和 500μm 直径微通道的圆度分别为 84.0%、61.5%和 82.3%。接下来，我们将这些不同的模型连接起来，实现了模拟小动脉网络的循环式血管模型。我们提出了一种使用蜡制成的中间连接器的新型连接方法，用于连接这些模型以制作循环模型。在流动实验中，所制造的模型没有泄漏，并且实现了无缝连接的循环模型。
