用于测定片剂制剂中草酸艾司西酞普兰的零阶分光光度法。
Zero order spectrophotometric method for estimation of escitalopram oxalate in tablet formulations.
作者信息
Sharma S, Rajpurohit H, Sonwal C, Bhandari A, Choudhary Vr, Jain T
机构信息
Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur - 342 008, India.
出版信息
J Young Pharm. 2010 Oct;2(4):420-3. doi: 10.4103/0975-1483.71626.
A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out using the zero order values (absorbance) measured at 238 nm. Calibration graph constructed at 238 nm was linear in concentration range of 2-20 µg/ml with correlation coefficient 0.9999. The method was found to be precise, accurate, specific, and validated as per ICH guidelines and can be used for determination of Escitalopram Oxalate in tablet formulations.
已开发出一种新的、简单、快速且可靠的零阶分光光度法，用于测定原料药和片剂剂型中的草酸艾司西酞普兰。使用在238 nm处测得的零阶值（吸光度）对药物进行定量测定。在238 nm处构建的校准曲线在2-20 µg/ml的浓度范围内呈线性，相关系数为0.9999。该方法被发现具有精密度、准确度、专属性，并根据ICH指南进行了验证，可用于片剂制剂中草酸艾司西酞普兰的测定。
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