比色法测定片剂剂型中草酸艾司西酞普兰的含量。
Colorimetric method for the estimation of escitalopram oxalate in tablet dosage form.
作者信息
Vetrichelvan T, Arul K, Sumithra M, Umadevi B
机构信息
Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, India.
出版信息
Indian J Pharm Sci. 2010 Mar;72(2):269-71. doi: 10.4103/0250-474X.65011.
Abstract
A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye. The extract of ion associates exhibited absorption maxima at 417 nm obeying Beer's law in the range of 2-10 µg/ml. The method is simple, precise and accurate with recovery of 98-102% and does not require any separation of soluble excipients from tablet dosage form.
摘要
基于与溴甲酚绿酸性染料形成氯仿可溶离子缔合物，开发了一种用于分析纯品和片剂中草酸艾司西酞普兰的比色法。离子缔合物提取物在417nm处有吸收最大值，在2 - 10μg/ml范围内符合比尔定律。该方法简单、精确、准确，回收率为98 - 102%，且无需从片剂剂型中分离可溶性辅料。
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Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.年龄和性别对成人及老年抑郁症患者中西酞普兰和去甲基西酞普兰稳态血浆浓度的影响。
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