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本文引用的文献

1
Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients.年龄和性别对成人及老年抑郁症患者中西酞普兰和去甲基西酞普兰稳态血浆浓度的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):952-6. doi: 10.1016/j.pnpbp.2005.06.001.
2
Liquid-phase microextraction and capillary electrophoresis of citalopram, an antidepressant drug.抗抑郁药物西酞普兰的液相微萃取与毛细管电泳分析
J Chromatogr A. 2001 Feb 9;909(1):87-93. doi: 10.1016/s0021-9673(00)00868-2.
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Simultaneous determination of citalopram, fluoxetine, paroxetine and their metabolites in plasma and whole blood by high-performance liquid chromatography with ultraviolet and fluorescence detection.高效液相色谱-紫外及荧光检测法同时测定血浆和全血中西酞普兰、氟西汀、帕罗西汀及其代谢物
J Chromatogr B Biomed Sci Appl. 1999 Nov 12;734(2):229-46. doi: 10.1016/s0378-4347(99)00352-7.
4
Determination of citalopram enantiomers in human plasma by liquid chromatographic separation on a Chiral-AGP column.采用手性-AGP柱液相色谱分离法测定人血浆中西酞普兰对映体。
J Chromatogr B Biomed Appl. 1996 Oct 25;685(2):299-305. doi: 10.1016/s0378-4347(96)00177-6.
5
Simplified high-performance liquid chromatographic method for the determination of citalopram and desmethylcitalopram in serum without interference from commonly used psychotropic drugs and their metabolites.一种简化的高效液相色谱法，用于测定血清中的西酞普兰和去甲基西酞普兰，不受常用精神药物及其代谢物的干扰。
J Chromatogr B Biomed Appl. 1996 Jan 12;675(1):83-8. doi: 10.1016/0378-4347(95)00347-9.
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Determination of plasma levels of citalopram and its demethylated and deaminated metabolites by gas chromatography and gas chromatography-mass spectrometry.
J Chromatogr. 1993 Jul 2;616(2):221-8. doi: 10.1016/0378-4347(93)80389-l.

比色法测定片剂剂型中草酸艾司西酞普兰的含量。

Colorimetric method for the estimation of escitalopram oxalate in tablet dosage form.

作者信息

Vetrichelvan T, Arul K, Sumithra M, Umadevi B

机构信息

Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, India.

出版信息

Indian J Pharm Sci. 2010 Mar;72(2):269-71. doi: 10.4103/0250-474X.65011.

DOI:10.4103/0250-474X.65011
PMID:20838541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2929796/
Abstract

A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye. The extract of ion associates exhibited absorption maxima at 417 nm obeying Beer's law in the range of 2-10 µg/ml. The method is simple, precise and accurate with recovery of 98-102% and does not require any separation of soluble excipients from tablet dosage form.

摘要

基于与溴甲酚绿酸性染料形成氯仿可溶离子缔合物，开发了一种用于分析纯品和片剂中草酸艾司西酞普兰的比色法。离子缔合物提取物在417nm处有吸收最大值，在2 - 10μg/ml范围内符合比尔定律。该方法简单、精确、准确，回收率为98 - 102%，且无需从片剂剂型中分离可溶性辅料。