Department of Gynecology, The Third Affiliated Hospital of Harbin Medical University, 150040 Harbin, China.
Med Oncol. 2012 Mar;29(1):318-23. doi: 10.1007/s12032-010-9817-4. Epub 2011 Jan 25.
We investigated the correlation of vascular endothelial growth factor C, matrix metalloproteinase-2, E-cadherin to explore mechanisms of vascular endothelial growth factor C in the metastasis of ovarian cancer and the relationship of prognosis. We applied immunohistochemistry to investigate the expression of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in ovarian tissues of 227 patients. We adopted Pearson chi-square test, Spearman correlation coefficient, univariate analysis, multivariate analysis, and Kaplan-Meier method. The positive rate of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in ovarian cancer was higher than that in borderline and benign tumor (P < 0.01). Vascular endothelial growth factor C was positively correlated with matrix metalloproteinase-2 (r = 0.665, P < 0.01) while negatively with E-cadherin(r = -0.185, P < 0.05). Univariate analysis showed clinical stage, pathologic grade, lymphatic metastasis, residual disease, chemotherapy, ascites, vascular endothelial growth factor C, and matrix metalloproteinase-2-influenced survival time (P < 0.05). In Cox multivariate analysis, all the aforementioned factors were found to be independent prognostic factors except pathologic grade. Vascular endothelial growth factor C was a new target to assess the prognosis of ovarian cancer. The expression of vascular endothelial growth factor C in ovarian cancer was related to matrix metalloproteinase-2 and E-cadherin.
我们研究了血管内皮生长因子 C、基质金属蛋白酶-2 和 E-钙黏蛋白的相关性，以探讨血管内皮生长因子 C 在卵巢癌转移中的作用机制及其与预后的关系。我们应用免疫组织化学方法检测了 227 例卵巢组织中血管内皮生长因子 C、基质金属蛋白酶-2 和 E-钙黏蛋白的表达情况。采用 Pearson 卡方检验、Spearman 相关系数、单因素分析、多因素分析和 Kaplan-Meier 法。卵巢癌中血管内皮生长因子 C、基质金属蛋白酶-2 和 E-钙黏蛋白的阳性率均高于交界性和良性肿瘤（P<0.01）。血管内皮生长因子 C 与基质金属蛋白酶-2 呈正相关（r=0.665，P<0.01），与 E-钙黏蛋白呈负相关（r=-0.185，P<0.05）。单因素分析显示临床分期、病理分级、淋巴转移、残留病灶、化疗、腹水、血管内皮生长因子 C 和基质金属蛋白酶-2 影响生存时间（P<0.05）。在 Cox 多因素分析中，除病理分级外，上述因素均为独立预后因素。血管内皮生长因子 C 是评估卵巢癌预后的新靶点。血管内皮生长因子 C 在卵巢癌中的表达与基质金属蛋白酶-2 和 E-钙黏蛋白有关。
