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基质金属蛋白酶与卵巢癌发生发展的关系

Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.

作者信息

Zhang Y, Chen Q

机构信息

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

Braz J Med Biol Res. 2017 May 18;50(6):e6104. doi: 10.1590/1414-431X20176104.

DOI:10.1590/1414-431X20176104
PMID:28538838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5479390/
Abstract

Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.

摘要

卵巢癌是最恶性的妇科癌症之一，死亡率很高。许多研究人员表明，基质金属蛋白酶（MMPs）在卵巢癌组织中具有显著高表达。MMPs被认为与卵巢癌的发生、发展、侵袭和转移有关。此外，一些研究发现，MMPs与金属蛋白酶组织抑制剂（TIMPs）之间的失衡与肿瘤的恶性表型有关。本文综述了MMPs在卵巢癌中的最新研究进展。对卵巢癌中MMP机制的研究将有助于开发有效的抗肿瘤药物，从而提高卵巢癌患者的生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ea/5479390/f72e81e6bb5a/1414-431X-bjmbr-1414-431X20176104-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ea/5479390/e518719d92b7/1414-431X-bjmbr-1414-431X20176104-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ea/5479390/f72e81e6bb5a/1414-431X-bjmbr-1414-431X20176104-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ea/5479390/e518719d92b7/1414-431X-bjmbr-1414-431X20176104-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ea/5479390/f72e81e6bb5a/1414-431X-bjmbr-1414-431X20176104-gf02.jpg

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Sci Rep. 2025 Mar 18;15(1):9228. doi: 10.1038/s41598-025-94111-0.
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