抗凝血酶III：结构与功能方面
Antithrombin III: structural and functional aspects.
作者信息
Mourey L, Samama J P, Delarue M, Choay J, Lormeau J C, Petitou M, Moras D
机构信息
Laboratoire de Cristallographie Biologique, IBMC du CNRS, Strasbourg, France.
出版信息
Biochimie. 1990 Aug;72(8):599-608. doi: 10.1016/0300-9084(90)90123-x.
Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.
抗凝血酶III是一种血浆糖蛋白，负责在血液凝固级联反应中抑制凝血酶。其裂解形式的X射线结构已被确定并精修至3.2埃分辨率。整体拓扑结构与丝氨酸蛋白酶抑制剂（serpin）超家族的另一个成员α1-抗胰蛋白酶相似。抗凝血酶III的生物活性由一种多糖——肝素介导。描述了这种效应物的结合位点。讨论了从天然结构到裂解结构可能的结构转变。
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