Whitley N T, Day M J
Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hertfordshire.
J Small Anim Pract. 2011 Feb;52(2):70-85. doi: 10.1111/j.1748-5827.2011.01024.x.
This review summarises the current understanding of immune response and T cell subsets in the context of development of autoimmunity in the dog. Mode of action and rational usage in immune-mediated disease in the dog are discussed for the following drugs: glucocorticoids, azathioprine, cyclophosphamide, ciclosporin, tacrolimus, human intravenous immunoglobulin, vincristine, danazol, leflunomide, mycophenolate mofetil and liposome-encapsulated clodronate. Disease mechanisms are discussed and published evidence for drug efficacy is scrutinised for five important immune-mediated diseases: immune-mediated haemolytic anaemia, immune-mediated thrombocytopenia, myasthenia gravis, glomerulonephritis and inflammatory bowel disease. Future strategies for more refined manipulation of adverse immune responses are presented.
本综述总结了目前对犬自身免疫性疾病发展过程中免疫反应和T细胞亚群的理解。讨论了以下药物在犬免疫介导疾病中的作用方式和合理用法：糖皮质激素、硫唑嘌呤、环磷酰胺、环孢素、他克莫司、人静脉注射免疫球蛋白、长春新碱、达那唑、来氟米特、霉酚酸酯和脂质体包裹的氯膦酸盐。讨论了疾病机制，并审视了五种重要免疫介导疾病（免疫介导性溶血性贫血、免疫介导性血小板减少症、重症肌无力、肾小球肾炎和炎症性肠病）的药物疗效公开证据。还提出了更精准调控不良免疫反应的未来策略。
