Université de Rouen, Dépt de Psychologie, 76821 Mont-Saint-Aignan Cedex, France.
Fundam Clin Pharmacol. 2012 Apr;26(2):271-8. doi: 10.1111/j.1472-8206.2010.00919.x. Epub 2011 Jan 25.
The effects of ethanol were examined on three tests of exploratory activity in two mouse strains. Although ethanol reduced open-field rearing in both strains, it increased ambulation only in the less active BALB/cAnN@Ico strain, not in the C57BL/6JIco strain. Likewise, ethanol increased open and enclosed arm entries in the elevated plus-maze only in the more anxious BALB/cAnN@Ico strain. However, both strains injected with ethanol emerged faster than placebo from a small chamber at doses not affecting behaviors in the other two tests. Significant correlations were found between emergence latencies on one hand and either slow stereotyped movements or open and enclosed arm entries on the other. The strain-specific effects may be attributable to differences in GABA(A) -related receptor binding or catalase activity.
乙醇对两种小鼠品系的三种探索性活动测试的影响进行了研究。虽然乙醇减少了两种品系的旷场活动，但仅在活动度较低的 BALB/cAnN@Ico 品系中增加了踱步，而在 C57BL/6JIco 品系中没有增加。同样，乙醇仅在更焦虑的 BALB/cAnN@Ico 品系中增加了高架十字迷宫的开放臂和封闭臂进入次数。然而，两种品系在不影响其他两种测试行为的剂量下，从小室中更快地出现，而不是安慰剂。一方面，潜伏期与慢刻板运动或开放和封闭臂进入之间存在显著相关性。这种品系特异性的影响可能归因于 GABA(A)相关受体结合或过氧化氢酶活性的差异。
