一锅不对称有机催化串联反应合成嗪衍生物。
A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives.
机构信息
Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Org Biomol Chem. 2011 Mar 21;9(6):1809-16. doi: 10.1039/c0ob00669f. Epub 2011 Jan 25.
PMID:21267494
Abstract
An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).
摘要
一种由手性仲胺催化的一锅串联反应可用于合成具有光学活性的恶嗪衍生物，通常可高收率（高达 99%）和优异对映选择性（高达>99%）得到相应取代的苯并[d]吡啶并[2,1-b][1,3]恶嗪衍生物。
相似文献
1
A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives.一锅不对称有机催化串联反应合成嗪衍生物。
Org Biomol Chem. 2011 Mar 21;9(6):1809-16. doi: 10.1039/c0ob00669f. Epub 2011 Jan 25.
2
Diastereo- and enantioselective synthesis of oxazine and oxazolidine derivatives with a chiral quaternary carbon center under multifunctional catalysis.手性季碳中心的噁嗪和恶唑烷衍生物的多相催化不对称及对映选择性合成。
Org Lett. 2011 Feb 18;13(4):564-7. doi: 10.1021/ol102643a. Epub 2011 Jan 14.
3
Highly efficient asymmetric synthesis of enantiopure dihydro-1,2-oxazines: dual-organocatalyst-promoted asymmetric cascade reaction.高效不对称合成手性纯二氢-1,2-恶嗪：双有机催化剂促进的不对称级联反应。
Org Lett. 2012 Aug 3;14(15):3818-21. doi: 10.1021/ol301218x. Epub 2012 Jul 18.
4
Dual-organocatalyst-promoted asymmetric cascade reaction: highly efficient construction of enantiopure fully substituted tetrahydro-1,2-oxazines.双有机催化剂促进的不对称级联反应：高效构建手性全取代四氢-1,2-恶嗪。
Org Lett. 2014 Feb 7;16(3):752-5. doi: 10.1021/ol403463h. Epub 2014 Jan 13.
5
A highly stereoselective organocatalytic tandem aminoxylation/aza-Michael reaction for the synthesis of tetrahydro-1,2-oxazines.一种用于合成四氢-1,2-恶嗪的高度立体选择性有机催化串联氨氧化/氮杂-Michael反应。
Org Lett. 2008 Oct 16;10(20):4585-8. doi: 10.1021/ol801864c. Epub 2008 Sep 13.
6
A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations.通过一锅法分子内双杂环化反应简便合成新型5H-吲唑并[3,2-b]苯并[d]-1,3-恶嗪。
J Org Chem. 2008 Jan 4;73(1):234-40. doi: 10.1021/jo702067z. Epub 2007 Dec 4.
7
A highly selective, organocatalytic route to chiral dihydro-1,2-oxazines.一种用于合成手性二氢-1,2-恶嗪的高选择性有机催化路线。
Org Lett. 2005 Sep 15;7(19):4189-91. doi: 10.1021/ol051577u.
8
A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.一种从酮类化合物出发制备手性1,2-恶嗪的高选择性有机催化途径。
Chem Commun (Camb). 2006 Aug 14(30):3211-3. doi: 10.1039/b606338a. Epub 2006 Jun 19.
9
Organocatalytic highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes.有机催化2-羟基-1,4-萘醌与硝基烯烃的高度对映选择性迈克尔加成反应。
Org Lett. 2008 Jul 3;10(13):2817-20. doi: 10.1021/ol800945e. Epub 2008 Jun 6.
10
Enantioselective synthesis of polycyclic coumarin derivatives catalyzed by an in situ formed primary amine-imine catalyst.手性胺-亚胺催化剂原位生成催化的多环香豆素衍生物的对映选择性合成。
Org Lett. 2011 Aug 19;13(16):4382-5. doi: 10.1021/ol201715h. Epub 2011 Jul 19.
Zotero 插件