通过一锅法分子内双杂环化反应简便合成新型5H-吲唑并[3,2-b]苯并[d]-1,3-恶嗪。
A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations.
作者信息
Butler Jeffrey D, Solano Danielle M, Robins Lori I, Haddadin Makhluf J, Kurth Mark J
机构信息
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.
出版信息
J Org Chem. 2008 Jan 4;73(1):234-40. doi: 10.1021/jo702067z. Epub 2007 Dec 4.
PMID:18052193
Abstract
The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.
摘要
母体5H-吲唑并[3,2-b]苯并[d]-1,3-恶嗪杂环以及一系列新型类似物已通过一锅法中的两步连续分子内杂环化反应合成。添加了各种不同的基团以探索该反应的适用范围，并提供许多新化合物用于生物筛选。
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