吡咯骨架用于模拟构象翻转。
Pyrrole-based scaffolds for turn mimics.
机构信息
Texas A & M University, Chemistry Department, College Station, Texas 77842, USA.
出版信息
Org Lett. 2011 Mar 4;13(5):980-3. doi: 10.1021/ol103022m. Epub 2011 Jan 26.
Abstract
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn.
摘要
两种氨基酸衍生的缩合产物被组合在一起，得到了同丙炔基胺 2。二氯铂用于将这些中间体环化，得到吡咯 3，在碱性条件下处理后，这些化合物坍塌成目标的二级结构模拟物 1。这些化合物的侧链与理想的 1 型 β-转角和反向 γ-转角重叠。
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