金（I）催化 N-丙炔基烯胺酮衍生物的氨基-Claisen 重排合成吡咯。
Synthesis of pyrroles by gold(I)-catalyzed amino-claisen rearrangement of N-propargyl enaminone derivatives.
机构信息
Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan.
出版信息
Org Lett. 2010 Jan 15;12(2):372-4. doi: 10.1021/ol902716n.
PMID:20025257
Abstract
The cationic N-heterocyclic carbene-gold(I) complex catalyzes the formation of tri- and tetrasubstituted pyrroles via the amino-Claisen rearrangement of N-propargyl beta-enaminone derivatives and the cyclization of alpha-allenyl beta-enaminone intermediates.
摘要
该阳离子 N-杂环卡宾-金（I）配合物通过 N-炔丙基β-烯胺酮衍生物的氨基-Claisen重排和α-烯丙基β-烯胺酮中间体的环化反应，催化三取代和四取代吡咯的形成。
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