Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Epilepsia. 2011 Apr;52(4):689-97. doi: 10.1111/j.1528-1167.2010.02928.x. Epub 2011 Jan 26.
Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).
We used radial atrophy mapping (RAM), a three-dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.
Subjects with a history of febrile seizures (n =15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI-II) score ≥ 14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI-II <14 (n = 29).
Contralateral hippocampal atrophy in TLE may be related to febrile seizures or depression.
神经影像学研究表明，热性惊厥史和抑郁症与颞叶癫痫（TLE）患者的海马体积缩小有关。
我们使用径向萎缩映射（RAM），一种三维（3D）表面建模工具，来测量 40 名单侧 TLE 患者的海马萎缩，这些患者有或没有热性惊厥史和抑郁症状。采用多元线性回归来单独确定协变量对局部萎缩的影响。
有热性惊厥史的患者（n=15）与无热性惊厥史的患者（n=25）相比，在与癫痫灶相对应的海马（CHC）的 CA1 和 CA3 亚区出现萎缩。贝克抑郁量表 II（BDI-II）得分≥14（n=11）的患者与 BDI-II<14 的患者（n=29）相比，在 CHC 的superoanterior 部分出现萎缩。
TLE 患者的对侧海马萎缩可能与热性惊厥或抑郁有关。
