Bidabadi Elham, Ahmadi Aliabadi Leila, Khosousi Mohammad-Javad, Mashouf Parham, Shahraki Tamkin, Tohidi Sepehr, Hasandokht Tolou
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Iran J Child Neurol. 2023 Winter;17(1):73-80. doi: 10.22037/ijcn.v17i1.38323. Epub 2023 Jan 1.
Tissue damage caused by febrile convulsion has not still been proved or refuted completely. Given the fact that lactate dehydrogenase as an intracellular enzyme can be increased due to tissue damage, we decided to evaluate serum and cerebrospinal fluid lactate dehydrogenase in children with febrile convulsion.
MATERIALS & METHODS: This is a cross-sectional study on 166 children aged 6-24 month, in three groups of simple febrile convulsion (n=56), complex febrile convulsion (n=27) with 3 different subgroups (recurrence in 24 hours, duration >15 minutes, and with focal components), and control (n=83). Patients' serum and cerebrospinal fluid specimens were collected after meeting the inclusion criteria. Demographic information was documented and patients' serum and cerebrospinal fluid lactate dehydrogenase and glucose were measured. Data were analyzed using SPSS software.
The mean serum lactate dehydrogenase in simple febrile convulsion, complex febrile convulsion, and controls were 501.57± 143.70, 553.07±160.22, and 505.87±98.73 U/L, respectively. The mean cerebrospinal fluid lactate dehydrogenase in simple, complex febrile convulsion, and control groups were 22.58±11.92, 29.48±18.18, and 21.56±17.32 U/L, respectively. Only cerebrospinal fluid lactate dehydrogenase difference between complex febrile convulsion and control group (p=0.039) (In the duration >15 minutes subgroup and controls, p=0.028) was statistically significant. There was a significant difference between sex and serum lactate dehydrogenase in thesame subgroup of complex group (p=0.012).
Complex febrile convulsion may lead to increase of lactate dehydrogenase in cns of CNS cellular damage.
热性惊厥所致的组织损伤尚未得到完全证实或证伪。鉴于乳酸脱氢酶作为一种细胞内酶可因组织损伤而升高，我们决定评估热性惊厥患儿的血清和脑脊液乳酸脱氢酶水平。
这是一项针对166名6至24个月大儿童的横断面研究，分为三组：单纯热性惊厥组（n = 56）、复杂热性惊厥组（n = 27），复杂热性惊厥组又分为3个不同亚组（24小时内复发、持续时间>15分钟、有局灶性成分）以及对照组（n = 83）。符合纳入标准后采集患者的血清和脑脊液标本。记录人口统计学信息，并检测患者血清和脑脊液中的乳酸脱氢酶及葡萄糖水平。使用SPSS软件进行数据分析。
单纯热性惊厥组、复杂热性惊厥组和对照组的血清乳酸脱氢酶平均水平分别为501.57±143.70、553.07±160.22和505.87±98.73 U/L。单纯热性惊厥组、复杂热性惊厥组和对照组的脑脊液乳酸脱氢酶平均水平分别为22.58±11.92、29.48±18.18和21.56±17.32 U/L。仅复杂热性惊厥组与对照组之间的脑脊液乳酸脱氢酶差异具有统计学意义（p = 0.039）（在持续时间>15分钟的亚组与对照组之间，p = 0.028）。在复杂组的同一亚组中，性别与血清乳酸脱氢酶之间存在显著差异（p = 0.012）。
复杂热性惊厥可能导致中枢神经系统细胞损伤，使中枢神经系统中的乳酸脱氢酶升高。
