Latchman D S
Department of Biochemistry, University College and Middlesex School of Medicine, London.
New Biol. 1990 Apr;2(4):297-303.
A very wide variety of biological processes are regulated by alternative splicing. By this means, a gene can be transcribed in several different tissues but in each tissue the RNA transcript is spliced in a particular way to produce a different mRNA and hence a different protein. It is now clear that alternative splicing is regulated by factors which are expressed in a tissue-specific manner and which are necessary for the splicing events to occur. This review will discuss the evidence for the existence of these factors, their nature, and the mechanisms by which they regulate splicing by interacting with sequences in the RNA.
多种生物学过程受可变剪接调控。通过这种方式，一个基因可在几种不同组织中进行转录，但在每个组织中，RNA转录本以特定方式进行剪接，从而产生不同的mRNA，进而产生不同的蛋白质。现在已经清楚，可变剪接受以组织特异性方式表达的因子调控，这些因子是剪接事件发生所必需的。本综述将讨论这些因子存在的证据、它们的性质，以及它们通过与RNA中的序列相互作用来调控剪接的机制。
