Forslund T, Kellokumpu I, Elomaa E, Arola J, Nuorva K
Division of Nephrology, Department of Internal Medicine, Central Finland Health Care District Hospital, Jyväskylä, Finland.
Clin Nephrol. 2011 Feb;75 Suppl 1:42-6. doi: 10.5414/cnp75042.
The concomitant existence of a non-malignant neuroendocrine tumor (NET) and membranous glomerulonephritis (MGN) is rare. We report a subject with kidney biopsy proven MGN and nephrotic syndrome in which a computerized scan tomography (CT) examination was performed revealing a pancreatic tumor. A pancreatectomy was performed and the tumor was shown to be a non-malignant NET with a malignant potential. Although treatment with corticosteroids was initiated remission of MGN was observed within the next month after pancreatectomy. The rapid remission observed shortly after pancreatectomy pointed to that tumor removal contributed to, and that neither spontaneous nor corticosteroid treatment alone did induce the rapid remission of the MGN. The coexistence of the two disorders NET and MGN is very rare, however. This is the first report on remission of MGN after pancreatectomy for a NET.
非恶性神经内分泌肿瘤（NET）与膜性肾小球肾炎（MGN）并存的情况较为罕见。我们报告了一名经肾活检证实为MGN并患有肾病综合征的患者，其计算机断层扫描（CT）检查发现胰腺肿瘤。进行了胰腺切除术，结果显示该肿瘤为具有恶性潜能的非恶性NET。尽管开始使用皮质类固醇进行治疗，但在胰腺切除术后的下个月内观察到MGN缓解。胰腺切除术后不久观察到的快速缓解表明肿瘤切除起到了作用，且单独的自发缓解或皮质类固醇治疗均未诱导MGN的快速缓解。然而，这两种疾病NET和MGN并存的情况非常罕见。这是关于NET胰腺切除术后MGN缓解的首例报告。
