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[膜性肾小球肾炎的远期治疗结果]

[The late results of treating membranous glomerulonephritis].

作者信息

Belovezhdov N, Robeva R, Dimitrova V

出版信息

Vutr Boles. 1990;29(3):53-60.

PMID:2284800
Abstract

27 patients with membranous glomerulonephritis treated with corticosteroids, anticoagulants and some with immunosuppressors are discussed. Men prevailed. Nephrotic syndrome proved by renal biopsy was found in 88.9%, proteinuria under 3.5 g/24 h--in 11.1%, arterial hypertension--in 18.5%, renal failure--in 14.8% of the patients. At the end of the follow up 15 patients (55.6%) showed a complete remission and 4 patients a partial remission. In 8 patients (29.6%) there was chronic renal failure and three of them had gone through hemodialysis. Comparing the patients with and without chronic renal failure we found that only the presence of impaired renal function as found by renal biopsy and the greated duration of the disease are of statistically significant importance for the prognosis of membranous glomerulonephritis. A 5 year survival of the patients treated actively is 100% and a 10 year survival is 94.9% which allows the assumption that treatment of membranous glomerulonephritis can lead to a permanent remission and preservation of renal function.

摘要

本文讨论了27例接受皮质类固醇、抗凝剂治疗,部分患者还接受免疫抑制剂治疗的膜性肾小球肾炎患者。男性患者居多。经肾活检证实,88.9%的患者患有肾病综合征,11.1%的患者24小时蛋白尿低于3.5g,18.5%的患者患有动脉高血压,14.8%的患者患有肾衰竭。随访结束时,15例患者(55.6%)完全缓解,4例患者部分缓解。8例患者(29.6%)出现慢性肾衰竭,其中3例接受了血液透析。比较有和没有慢性肾衰竭的患者,我们发现只有肾活检发现的肾功能损害以及疾病持续时间更长对膜性肾小球肾炎的预后具有统计学意义。积极治疗的患者5年生存率为100%,10年生存率为94.9%,这使得我们可以假设膜性肾小球肾炎的治疗可以导致永久性缓解并保留肾功能。

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