Dahan S, Elefant E, Girard I, Azcona B, Champion V, Mitanchez D
Service de néonatologie, hôpital Armand-Trousseau, AP-HP, faculté de médecine, université Pierre-et-Marie-Curie, 26, avenue du Dr-Arnold-Netter, 75571 Paris cedex 12, France.
Arch Pediatr. 2011 Mar;18(3):287-90. doi: 10.1016/j.arcped.2010.12.003. Epub 2011 Jan 26.
We report the case of a hypotrophic twin who presented neonatal abstinence syndrome to buprenorphine and developed neonatal seizures when the substitutive treatment by morphine was stopped. The other eutrophic twin did not develop withdrawal symptoms. This case demonstrates the unpredictable nature of transplacental transfer of buprenorphine. It also shows that neonatal abstinence syndrome can be potentially severe and that morphine treatment is not without risk.
我们报告了一例发育迟缓的双胞胎病例，该患儿对丁丙诺啡出现新生儿戒断综合征，在停用吗啡替代治疗时发生新生儿惊厥。另一个发育正常的双胞胎未出现戒断症状。该病例证明了丁丙诺啡经胎盘转移具有不可预测性。它还表明新生儿戒断综合征可能很严重，且吗啡治疗并非没有风险。
