Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK CB2 1GA.
Trends Immunol. 2011 Mar;32(3):104-9. doi: 10.1016/j.it.2010.12.005. Epub 2011 Jan 25.
Signaling by the toll-like receptor (TLR) and interleukin-1 receptor superfamily requires the adapter protein myeloid differentiation primary response protein 88 (MyD88). The recent determination of the structure of the so-called Myddosome provides us with new insights into the structural basis for innate immune signaling. Other information on the biochemistry and genetics of MyD88 and other adapters, such as MyDD adapter-like and TRIF-related adapter molecule, allows us to describe in some detail the signaling process activated by TLRs and provides new insights into the role these important proteins play in innate immunity.
Toll 样受体 (TLR) 和白细胞介素-1 受体超家族的信号转导需要衔接蛋白髓样分化初级反应蛋白 88（MyD88）。最近所谓的 Myddosome 结构的确定为我们提供了对先天免疫信号转导结构基础的新见解。关于 MyD88 和其他衔接子（如 MyDD 衔接子样和 TRIF 相关衔接分子）的生物化学和遗传学的其他信息，使我们能够详细描述 TLR 激活的信号转导过程，并深入了解这些重要蛋白质在先天免疫中的作用。
