Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China.
Int J Mol Sci. 2023 Jan 5;24(2):1010. doi: 10.3390/ijms24021010.
Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it presents a proportional relationship with the fatality of many diseases. Therefore, the prevention and treatment of thrombocytopenia is of great importance. The expression of Toll-like receptors (TLRs) is one of the most relevant characteristics of thrombopoiesis and the platelet inflammatory function. We know that the TLR family is found on the surface or inside almost all cells, where they perform many immune functions. Of those, TLR2 and TLR4 are the main stress-inducing members and play an integral role in inflammatory diseases and platelet production and function. Therefore, the aim of this review is to present and discuss the relationship between platelets, inflammation and the TLR family and extend recent research on the influence of the TLR2 and TLR4 pathways and the regulation of platelet production and function. Reviewing the interaction between TLRs and platelets in inflammation may be a research direction or program for the treatment of thrombocytopenia-related and inflammatory-related diseases.
血小板是除红细胞外第二丰富的血液成分，可参与多种生理和病理功能。除了其在止血和血栓形成中的传统作用外，它在炎症性疾病中也起着不可或缺的作用。然而，血小板减少症是临床上常见的血液学问题，它与许多疾病的死亡率呈比例关系。因此，预防和治疗血小板减少症非常重要。Toll 样受体 (TLR) 的表达是造血和血小板炎症功能的最相关特征之一。我们知道，TLR 家族存在于几乎所有细胞的表面或内部，在那里它们发挥许多免疫功能。其中，TLR2 和 TLR4 是主要的应激诱导成员，在炎症性疾病和血小板生成和功能中发挥着重要作用。因此，本综述的目的是阐述并讨论血小板、炎症和 TLR 家族之间的关系，并扩展关于 TLR2 和 TLR4 途径的影响以及对血小板生成和功能的调节的最新研究。研究 TLRs 与炎症中的血小板相互作用可能是治疗与血小板减少症相关和炎症相关疾病的一个研究方向或方案。
