NHC 催化/钛(IV)介导的烯醛高非对映选择性和对映选择性二聚反应。
NHC-catalyzed/titanium(IV)-mediated highly diastereo- and enantioselective dimerization of enals.
机构信息
Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, USA.
出版信息
Org Lett. 2011 Mar 4;13(5):1068-71. doi: 10.1021/ol103112v. Epub 2011 Jan 27.
Abstract
An NHC-catalyzed, diastereo- and enantioselective dimerization of enals has been developed. The use of Ti(Oi-Pr)(4) is a key element for the reactivity and selectivity of this process. The cyclopentenes are obtained with high levels of diastereo- and enantioselectivity and their synthetic utility is demonstrated by functionalization of the product alkene.
摘要
一种 NHC 催化的烯醛的非对映选择性和对映选择性二聚反应已经被开发出来。Ti(Oi-Pr)(4)的使用是该过程反应性和选择性的关键因素。环戊烯以高非对映选择性和对映选择性获得，并且通过产物烯烃的官能化证明了它们的合成实用性。
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