Department of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul, Korea.
Skin Res Technol. 2011 Aug;17(3):288-94. doi: 10.1111/j.1600-0846.2010.00495.x. Epub 2011 Jan 28.
BACKGROUND/PURPOSE: We have investigated the changes of seborrheic dermatitis (SD) on the hair shaft in the morphological and physical properties using atomic force microscopy (AFM).
Hair samples were obtained from the lesional and perilesional regions in 15 patients with SD. Fifteen healthy adults were included as the control group. From the topography of hair obtained by AFM, the height of the scale, step height, roughness, diameter, and pit were determined.
The scale thickness of the SD-affected hair was sevenfold more than in the control hair showing statistically significance. The lesional hair showed greater roughness parameters of Sa, Sq, and Sz than the perilesional and the control hair, but this difference was not significant. The cuticle of the lesional hair was significantly damaged while perilesional hair showed a very distinct cuticle structure with smooth edges and a regular interval between the cuticles. The diameter of the lesional hair was significantly lesser by 10-35% than that of the perilesional hair. The pit was rarely observed in the SD-affected hair collected from both the lesional and perilesional regions.
The changes in the hair shaft affected SD was measured using AFM non-invasively. AFM could be a useful tool in monitoring the treatment response and the severity of SD.
背景/目的：我们使用原子力显微镜（AFM）研究了头皮脂溢性皮炎（SD）在毛发形态和物理性质上的变化。
从 15 例 SD 患者的皮损和非皮损区采集毛发样本，将 15 例健康成年人作为对照组。从 AFM 获得的毛发形貌图中，确定鳞片高度、台阶高度、粗糙度、直径和凹坑。
SD 受累毛发的鳞片厚度比对照组毛发厚七倍，差异有统计学意义。与非皮损区和对照组毛发相比，皮损区毛发的 Sa、Sq 和 Sz 粗糙度参数更大，但差异无统计学意义。皮损区毛发的表皮明显受损，而非皮损区毛发的表皮结构非常明显，边缘光滑，表皮之间的间隔规则。皮损区毛发的直径比非皮损区毛发小 10-35%。在从皮损区和非皮损区采集的 SD 受累毛发中，很少观察到凹坑。
使用 AFM 非侵入性地测量了受 SD 影响的毛发轴的变化。AFM 可能是监测 SD 治疗反应和严重程度的有用工具。
