Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Clin Exp Dermatol. 2012 Mar;37(2):156-63. doi: 10.1111/j.1365-2230.2011.04212.x.
Psoriasis affects not only the soft keratin of the skin, but also hard keratin, such as nails and hair. However, few studies have described the changes induced in the hair of patients with psoriasis.
Using atomic force microscopy (AFM), we investigated the morphological property of hair samples taken from the scalp of patients with psoriasis.
Lesional and nonlesional hairs taken from 15 patients with scalp psoriasis were investigated. Hairs from 15 healthy adults were also examined as controls. Using AFM, surface images were taken of an area of 20 × 20 μm(2), with 512 × 512 pixels and a scan speed of 0.8 lines/s. results: Pits were frequently seen in the hair shafts of patients with psoriasis, similar to those seen in their nail plates. Macropit number, scale thickness and surface roughness were all significantly increased in lesional hairs compared with both nonlesional and control hairs, and macropits and scale thickness were also increased in nonlesional hairs compared with control hairs.
The hair shafts of patients with scalp psoriasis exhibited the same macropits seen in their nails. Both lesional and nonlesional hairs had similar changes in morphological structure compared with controls. This supports the generalized nature of psoriasis, with changes in hair structure being analogous to the changes seen in skin and nails.
银屑病不仅影响皮肤的软角蛋白，还影响硬角蛋白，如指甲和毛发。然而，很少有研究描述银屑病患者毛发的变化。
我们使用原子力显微镜（AFM）研究了来自银屑病患者头皮的毛发样本的形态特性。
研究了 15 例头皮银屑病患者的皮损和非皮损毛发。还检查了 15 例健康成年人的毛发作为对照。使用 AFM，在 20×20μm²的区域内拍摄表面图像，像素为 512×512，扫描速度为 0.8 线/秒。结果：银屑病患者的毛发杆上经常出现凹坑，类似于指甲板上的凹坑。与非皮损毛发和对照毛发相比，皮损毛发的宏观凹陷数量、鳞屑厚度和表面粗糙度均显著增加，与对照毛发相比，非皮损毛发的宏观凹陷数量和鳞屑厚度也增加。
头皮银屑病患者的毛发杆表现出与指甲相同的宏观凹陷。与对照组相比，皮损和非皮损毛发的形态结构均有相似的变化。这支持了银屑病的普遍性，毛发结构的变化与皮肤和指甲的变化类似。
