托特罗定治疗伴有或不伴有排尿功能障碍的女性膀胱过度活动症后尿动力学参数的变化。

Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction.

作者信息

Wu Wen-Yih, Hsiao Sheng-Mou, Chang Ting-Chen, Lin Ho-Hsiung

机构信息

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Pan-Chiao, Taiwan.

出版信息

J Obstet Gynaecol Res. 2011 May;37(5):436-41. doi: 10.1111/j.1447-0756.2010.01370.x. Epub 2011 Jan 27.

DOI:10.1111/j.1447-0756.2010.01370.x

PMID:21272154

Abstract

AIM

To investigate changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome, especially in patients with voiding dysfunction.

METHODS

Between January and December 2006, 44 patients were enrolled for six months of treatment with tolterodine. Pre-treatment and post-treatment urodynamic studies were scheduled for the enrolled patients.

RESULTS

Among the remaining 33 patients (11 dropped out), bladder capacity (P < 0.001) and post-void residual urine (P = 0.009) increased, and functional urethral length (P = 0.049) and pad weight test (P = 0.03) decreased after treatment. Besides this, detrusor pressure at maximal urine flow, functional urethral length, maximal urethral pressure and maximal urethral closure pressure were less affected by tolterodine in patients with voiding dysfunction, compared to those without voiding dysfunction.

CONCLUSIONS

Tolterodine treatment increased bladder capacity and decreased urine leakage; however, some urodynamic parameters in patients with voiding dysfunction were less affected by tolterodine treatment.

摘要

目的

探讨托特罗定治疗女性膀胱过度活动症后尿动力学参数的变化，尤其是对存在排尿功能障碍患者的影响。

方法

2006年1月至12月，44例患者纳入托特罗定治疗6个月的研究。对纳入患者进行治疗前和治疗后的尿动力学检查。

结果

在其余33例患者（11例退出）中，治疗后膀胱容量（P < 0.001）和残余尿量（P = 0.009）增加，功能性尿道长度（P = 0.049）和尿垫试验重量（P = 0.03）降低。此外，与无排尿功能障碍的患者相比，托特罗定对存在排尿功能障碍患者的最大尿流逼尿肌压力、功能性尿道长度、最大尿道压力和最大尿道闭合压力影响较小。