Department of Obstetrics, Gynecology, and Women's Health, School of Medicine, University of Louisville, Louisville, KY, USA.
Am J Obstet Gynecol. 2011 Apr;204(4):334.e1-5. doi: 10.1016/j.ajog.2010.11.024. Epub 2011 Jan 26.
We sought to determine whether tetanus-diphtheria-pertussis vaccination (Tdap) in pregnancy provides newborns antibodies against pertussis when compared to mothers who did not receive Tdap.
Paired maternal and umbilical cord blood samples were collected at the time of delivery and the serum stored at -86°C. For each paired sample of maternal and cord blood, the medical chart and vaccine history was reviewed to determine whether Tdap was received or not.
Newborns born from mothers who received Tdap during pregnancy had significantly higher concentrations of diphtheria antitoxin (P < .001), tetanus antitoxin (P = .004), and antibodies to pertussis toxin (P < .001), filamentous hemagglutinin (P = .002), pertactin (P < .001), and fimbriae 2/3 (P < .001) when compared to newborns from mothers who did not receive Tdap. There was a significant increase in the odds that newborns from mothers who received Tdap during pregnancy have antibodies that may provide protection against diphtheria (P = .0141), pertussis toxin (P < .0001), and fimbriae 2/3 (P = .0146).
Administering Tdap during pregnancy increases antibody titers against diphtheria and pertussis antigens. Maternal Tdap may prevent neonatal pertussis infection.
我们旨在确定与未接受 Tdap 疫苗接种的母亲相比，妊娠期间接种破伤风白喉无细胞百日咳疫苗（Tdap）是否能为新生儿提供针对百日咳的抗体。
在分娩时采集配对的母亲和脐带血样本，并将血清储存在-86°C。对于每对来自母亲和脐带的配对样本，检查病历和疫苗接种史以确定是否接受了 Tdap 疫苗接种。
与未接受 Tdap 疫苗接种的母亲所生的新生儿相比，在妊娠期间接受 Tdap 疫苗接种的母亲的新生儿中，白喉抗毒素（P <.001）、破伤风抗毒素（P =.004）和针对百日咳毒素（P <.001）、丝状血凝素（P =.002）、 pertactin（P <.001）和菌毛 2/3（P <.001）的浓度明显更高。与未接受 Tdap 疫苗接种的母亲所生的新生儿相比，接受 Tdap 疫苗接种的母亲的新生儿具有针对白喉（P =.0141）、百日咳毒素（P <.0001）和菌毛 2/3（P =.0146）的可能提供保护的抗体的可能性显著增加。
在妊娠期间接种 Tdap 可增加针对白喉和百日咳抗原的抗体滴度。母体 Tdap 可能预防新生儿百日咳感染。
