Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY, USA.
Am J Obstet Gynecol. 2011 Apr;204(4):364.e1-8. doi: 10.1016/j.ajog.2010.11.006. Epub 2011 Jan 26.
Magnesium sulfate is proposed to have neuroprotective effects in the offspring. We examined the effects of maternal magnesium sulfate administration on maternal and fetal inflammatory responses in a rat model of maternal infection.
Pregnant rats were injected with saline, Gram-negative bacterial endotoxin lipopolysaccharide or lipopolysaccharide with magnesium sulfate (pre- and/or after lipopolysaccharide) to mimic infection. Maternal blood, amniotic fluid, fetal blood, and fetal brains were collected 4 hours after lipopolysaccharide and assayed for tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC. In addition, the effect of magnesium sulfate on cytokine production by an astrocytoma cell line was assessed.
Lipopolysaccharide administration induced tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC expression in maternal and fetal compartments. Maternal magnesium sulfate treatment significantly attenuated lipopolysaccharide-induced multiple proinflammatory mediator levels in maternal and fetal compartments.
Antenatal magnesium sulfate administration significantly ameliorated maternal, fetal, and gestational tissue-associated inflammatory responses in an experimental model of maternal infection.
硫酸镁具有保护后代神经的作用。我们通过建立大鼠母体内毒素感染模型，研究了母体硫酸镁给药对母胎炎症反应的影响。
给怀孕大鼠注射生理盐水、革兰氏阴性细菌内毒素脂多糖或脂多糖加硫酸镁（脂多糖前及/或后）以模拟感染。在脂多糖注射 4 小时后收集母血、羊水、胎血和胎脑，并检测肿瘤坏死因子、白细胞介素-6、单核细胞趋化蛋白-1 和生长相关癌基因 KC。此外，还评估了硫酸镁对星形胶质细胞瘤细胞系细胞因子产生的影响。
脂多糖给药诱导母胎各部位肿瘤坏死因子、白细胞介素-6、单核细胞趋化蛋白-1 和生长相关癌基因 KC 的表达。母体硫酸镁治疗显著减轻了母胎各部位脂多糖诱导的多种促炎介质水平。
在母体内毒素感染的实验模型中，产前硫酸镁给药显著改善了母体、胎儿和妊娠组织相关的炎症反应。
