γ-干扰素与肿瘤坏死因子在全身热疗中的协同作用。
The synergism of gamma-interferon and tumor necrosis factor in whole body hyperthermia.
作者信息
Rosen P
机构信息
Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
出版信息
Med Hypotheses. 1990 Nov;33(3):173-4. doi: 10.1016/0306-9877(90)90170-j.
PMID:2127298
Abstract
It is suggested that gamma-interferon (gamma-IFN) can be added to tumor necrosis factor (TNF) to improve therapy in whole body hyperthermia (WBH). The amount of r-HTNF is about 3.5 x 10(6) units per week with about 3.5 x 10(4) units of rH gamma-INF intravenously. The body temperature should be 40 degrees C for one half hour. An i.p. injection of secobarbital (24 mg/kg) should be given as well.
摘要
建议可将γ-干扰素（γ-IFN）添加到肿瘤坏死因子（TNF）中，以改善全身热疗（WBH）的治疗效果。重组人肿瘤坏死因子（r-HTNF）的用量约为每周3.5×10⁶单位，同时静脉注射约3.5×10⁴单位的重组人γ-干扰素（rHγ-INF）。体温应维持在40摄氏度半小时。此外，应腹腔注射速可巴比妥（24毫克/千克）。
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