Pendl G, Grunert P, Graf M, Czech T
Department of Neurosurgery, University of Graz, Austria.
Neurochirurgia (Stuttg). 1990 Oct;33 Suppl 1:27-9. doi: 10.1055/s-2008-1053592.
Seventy patients with intractable epilepsy were surgically treated. Thirty-three patients underwent a stereotactic procedure and in all as a first-stage operation fornicotomy was performed. Because of inadequate results in 14 patients, an additional stereotactic intervention was necessary; the targets were amygdala, thalamus, and Forel's H-field, and the final outcome of these patients was 9 (27%) seizure-free, 19 (58%) improved, and 5 (15%) unchanged. In 3 patients a selective amygdalo-hippocampectomy was performed with 2 seizure-free patients and one with improvement. Topectomy in focal epilepsy in 5 patients resulted in freedom from seizures in all cases. In 23 patients a lobectomy was performed; 10 (43%) were seizures-free, 8 (35%) were improved, and 5 (22%) were unchanged. In 6 patients only a pathological lesion was resected. Our results speak in favour of ablative surgery. However, stereotactic operations are indicated in cases with secondary generalization and dissipated foci on the dominant hemisphere.
70例难治性癫痫患者接受了手术治疗。33例患者接受了立体定向手术,所有患者均将穹窿切开术作为一期手术进行。由于14例患者效果不佳,需要进行额外的立体定向干预;靶点为杏仁核、丘脑和Forel氏H区,这些患者的最终结果为9例(27%)无癫痫发作,19例(58%)改善,5例(15%)无变化。3例患者进行了选择性杏仁核-海马切除术,其中2例无癫痫发作,1例有所改善。5例局灶性癫痫患者进行了脑局部切除术,所有病例均无癫痫发作。23例患者进行了叶切除术;10例(43%)无癫痫发作,8例(35%)改善,5例(22%)无变化。6例患者仅切除了病理性病变。我们的结果支持切除性手术。然而,立体定向手术适用于继发性全身性发作和优势半球病灶分散的病例。