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癫痫的外科治疗

Surgical treatment of epilepsy.

作者信息

Pendl G, Grunert P, Graf M, Czech T

机构信息

Department of Neurosurgery, University of Graz, Austria.

出版信息

Neurochirurgia (Stuttg). 1990 Oct;33 Suppl 1:27-9. doi: 10.1055/s-2008-1053592.

Abstract

Seventy patients with intractable epilepsy were surgically treated. Thirty-three patients underwent a stereotactic procedure and in all as a first-stage operation fornicotomy was performed. Because of inadequate results in 14 patients, an additional stereotactic intervention was necessary; the targets were amygdala, thalamus, and Forel's H-field, and the final outcome of these patients was 9 (27%) seizure-free, 19 (58%) improved, and 5 (15%) unchanged. In 3 patients a selective amygdalo-hippocampectomy was performed with 2 seizure-free patients and one with improvement. Topectomy in focal epilepsy in 5 patients resulted in freedom from seizures in all cases. In 23 patients a lobectomy was performed; 10 (43%) were seizures-free, 8 (35%) were improved, and 5 (22%) were unchanged. In 6 patients only a pathological lesion was resected. Our results speak in favour of ablative surgery. However, stereotactic operations are indicated in cases with secondary generalization and dissipated foci on the dominant hemisphere.

摘要

70例难治性癫痫患者接受了手术治疗。33例患者接受了立体定向手术,所有患者均将穹窿切开术作为一期手术进行。由于14例患者效果不佳,需要进行额外的立体定向干预;靶点为杏仁核、丘脑和Forel氏H区,这些患者的最终结果为9例(27%)无癫痫发作,19例(58%)改善,5例(15%)无变化。3例患者进行了选择性杏仁核-海马切除术,其中2例无癫痫发作,1例有所改善。5例局灶性癫痫患者进行了脑局部切除术,所有病例均无癫痫发作。23例患者进行了叶切除术;10例(43%)无癫痫发作,8例(35%)改善,5例(22%)无变化。6例患者仅切除了病理性病变。我们的结果支持切除性手术。然而,立体定向手术适用于继发性全身性发作和优势半球病灶分散的病例。

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