Kononen J, Koistinaho J, Alho H
Department of Biomedical Sciences, University of Tampere, Finland.
Neurosci Lett. 1990 Nov 27;120(1):105-8. doi: 10.1016/0304-3940(90)90179-d.
The circadian variation in the expression of Fos protein(s) in the rat brain was studied immunohistochemically. The number of Fos-immunoreactive nuclei was statistically increased in the hippocampus and caudate putamen after the onset of darkness. Unlike the cells of the hippocampus and putamen the cells in the suprachiasmatic nucleus displayed a circadian variation with the lowest values during the nighttime and the highest in the morning. As the circadian rhythm of Fos expression in the normal rat brain may correlate with that reported for ACTH and corticosteroids, the results suggest that the fos gene is involved in mediating physiological activation of specific neuron populations of intact rats.
采用免疫组织化学方法研究了大鼠脑内Fos蛋白表达的昼夜变化。黑暗开始后，海马和尾状壳核中Fos免疫反应性细胞核的数量在统计学上有所增加。与海马和壳核的细胞不同，视交叉上核中的细胞呈现出昼夜变化，夜间值最低，早晨最高。由于正常大鼠脑中Fos表达的昼夜节律可能与促肾上腺皮质激素（ACTH）和皮质类固醇的报道相关，结果表明fos基因参与介导完整大鼠特定神经元群体的生理激活。
