Second Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece.
Epilepsy Behav. 2011 Feb;20(2):414-7. doi: 10.1016/j.yebeh.2010.12.028. Epub 2011 Jan 26.
Transient epileptic amnesia (TEA) is a recently described, typically misdiagnosed at presentation, distinctive syndrome, characterized by recurrent, brief attacks of memory loss in middle-aged or elderly people, accompanied by significant interictal memory difficulties. We describe the clinical, neuroimaging, electrophysiological, and neuropsychological characteristics of three patients fulfilling the proposed criteria for TEA, initially referred to our memory clinic for evaluation and treatment of probable dementia. Neuropsychological performance on admission and 6 months after treatment demonstrated a broad range of performance on measures of executive function, lower than expected visuospatial perception, and poor autobiographical memory. TEA should be included in the differential diagnosis of dementia to avoid misdiagnosis and needless medication. It is a benign and treatable condition, yet the associated decline in autobiographical and remote memory despite antiepileptic therapy poses challenges for further research.
短暂性癫痫性遗忘症（TEA）是一种新近描述的疾病，在发病时通常被误诊，具有独特的综合征特征，表现为中年或老年人反复发作的短暂性记忆丧失，伴有明显的发作间期记忆困难。我们描述了 3 名符合 TEA 拟议标准的患者的临床、神经影像学、电生理学和神经心理学特征，他们最初因疑似痴呆被转至我们的记忆诊所进行评估和治疗。治疗后 6 个月的神经心理学表现显示，在执行功能、低于预期的视空间感知以及较差的自传体记忆等方面的表现存在广泛差异。TEA 应纳入痴呆症的鉴别诊断，以避免误诊和不必要的药物治疗。它是一种良性且可治疗的疾病，但抗癫痫治疗后自传体记忆和远记忆的下降给进一步研究带来了挑战。
