Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Epilepsy Behav. 2011 Feb;20(2):410-3. doi: 10.1016/j.yebeh.2010.12.026. Epub 2011 Jan 22.
Transient epileptic amnesia is a rare but probably underrecognized form of temporal lobe epilepsy, which typically manifests as episodic isolated memory loss. Consequently, transient epileptic amnesia may be readily misdiagnosed as a nonepileptic memory dysfunction in older individuals. When appropriately recognized, it has been described as a treatment-responsive syndrome amenable to antiepileptic drugs. We describe a patient with drug-resistant transient epileptic amnesia treated with unilateral temporal lobectomy. Prolonged postictal slowing in the mesial temporal structures was evident on invasive electroencephalography 5 hours after the occurrence of a brief focal seizure. These findings support the theory of a Todd phenomenon as the underlying pathophysiological mechanism in transient epileptic amnesia.
短暂性癫痫性遗忘症是一种罕见但可能被低估的颞叶癫痫形式，其典型表现为阵发性孤立性记忆丧失。因此，短暂性癫痫性遗忘症在老年人中可能很容易被误诊为非癫痫性记忆功能障碍。当得到适当识别时，它被描述为一种对抗癫痫药物有反应的综合征。我们描述了一例耐药性短暂性癫痫性遗忘症患者，接受了单侧颞叶切除术治疗。在短暂局灶性发作发生后 5 小时，侵入性脑电图显示内侧颞叶结构中出现长时间的发作后减速。这些发现支持 Todd 现象是短暂性癫痫性遗忘症潜在病理生理学机制的理论。
