一种新的、低发生率的红细胞抗原（HOFM），与C抗原减弱相关。

A new, low-incidence red cell antigen (HOFM), associated with depressed C antigen.

作者信息

Hoffmann J J, Overbeeke M A, Kaita H, Loomans A A

机构信息

Department of Clinical Laboratories, Catharina Hospital, Eindhoven, The Netherlands.

出版信息

Vox Sang. 1990;59(4):240-3. doi: 10.1111/j.1423-0410.1990.tb00245.x.

DOI:10.1111/j.1423-0410.1990.tb00245.x

PMID:2127329

Abstract

A case of mild hemolytic disease of the newborn is presented which was caused by an antibody to a hitherto unknown antigen of low incidence. This antigen, now designated as HOFM (ISBT number 700050) was detected in 6 relatives, and in all of them, it was associated with an unusually weakened expression of C antigen. The serological data indicate that HOFM may be part of the Rh system, but the genetic data, although supportive of this interpretation, are inconclusive.

摘要

本文报告一例轻度新生儿溶血病，其由针对一种迄今未知的低发生率抗原的抗体所致。这种抗原现命名为HOFM（国际输血协会编号700050），在6名亲属中被检测到，并且在所有这些亲属中，它都与C抗原的异常减弱表达相关。血清学数据表明HOFM可能是Rh系统的一部分，但遗传学数据虽支持这一解释，却尚无定论。